التفاصيل البيبلوغرافية
| العنوان: |
The HMOX2 polymorphism contributes to the carotid body chemoreflex in European sea-level residents by regulating hypoxic ventilatory responses |
| المؤلفون: |
Pierre Fabries, Catherine Drogou, Fabien Sauvet, Olivier Nespoulous, Marie-Claire Erkel, Vincent Marchandot, Walid Bouaziz, Benoît Lepetit, Anne-Pia Hamm-Hornez, Alexandra Malgoyre, Nathalie Koulmann, Danielle Gomez-Merino, Mounir Chennaoui |
| المصدر: |
Frontiers in Medicine, Vol 9 (2022) |
| بيانات النشر: |
Frontiers Media S.A., 2022. |
| سنة النشر: |
2022 |
| المجموعة: |
LCC:Medicine (General) |
| مصطلحات موضوعية: |
acute hypoxia, exercise, chemosensitivity, heme oxygenase-2, genetics, individual vulnerability, Medicine (General), R5-920 |
| الوصف: |
This study investigates whether a functional single nucleotide polymorphism of HMOX2 (heme oxygenase-2) (rs4786504 T>C) is involved in individual chemosensitivity to acute hypoxia, as assessed by ventilatory responses, in European individuals. These responses were obtained at rest and during submaximal exercise, using a standardized and validated protocol for exposure to acute normobaric hypoxia. Carriers of the ancestral T allele (n = 44) have significantly lower resting and exercise hypoxic ventilatory responses than C/C homozygous carriers (n = 40). In the literature, a hypoxic ventilatory response threshold to exercise has been identified as an independent predictor of severe high altitude-illness (SHAI). Our study shows that carriers of the T allele have a higher risk of SHAI than carriers of the mutated C/C genotype. Secondarily, we were also interested in COMT (rs4680 G > A) polymorphism, which may be indirectly involved in the chemoreflex response through modulation of autonomic nervous system activity. Significant differences are present between COMT genotypes for oxygen saturation and ventilatory responses to hypoxia at rest. In conclusion, this study adds information on genetic factors involved in individual vulnerability to acute hypoxia and supports the critical role of the ≪ O2 sensor ≫ - heme oxygenase-2 - in the chemosensitivity of carotid bodies in Humans. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2296-858X |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fmed.2022.1000786/full; https://doaj.org/toc/2296-858X |
| DOI: |
10.3389/fmed.2022.1000786 |
| URL الوصول: |
https://doaj.org/article/5e328c69f01e4c1c97a1dc86cd6264ee |
| رقم الانضمام: |
edsdoj.5e328c69f01e4c1c97a1dc86cd6264ee |
| قاعدة البيانات: |
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