Academic Journal
Glucose-driven transformable complex eliminates biofilm and alleviates inflamm-aging for diabetic periodontitis therapy
| العنوان: | Glucose-driven transformable complex eliminates biofilm and alleviates inflamm-aging for diabetic periodontitis therapy |
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| المؤلفون: | Rongbing Tang, Yanrong Ren, Yueting Zhang, Mengying Yin, Xinyu Ren, Qiangyuan Zhu, Cen Gao, Wei Zhang, Guangxiu Liu, Bin Liu |
| المصدر: | Materials Today Bio, Vol 20, Iss , Pp 100678- (2023) |
| بيانات النشر: | Elsevier, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Medicine (General) LCC:Biology (General) |
| مصطلحات موضوعية: | Transformable complex, Hyperglycemia, Periodontitis, Biofilm penetration, Imflamm-aging, Medicine (General), R5-920, Biology (General), QH301-705.5 |
| الوصف: | Diabetic periodontitis is a major complication of diabetes, which has a deep involvement in teeth loss and more serious systematic diseases, including Alzheimer's disease, atherosclerosis and cancers. Diabetic periodontitis is difficult to treat because of recalcitrant infection and hyperglycemia-induced tissue dysfunction. Current treatments fail to completely eliminate infection due to the diffusion-reaction inhibition of biofilm, and ignore the tissue dysfunction. Here, we design a glucose-driven transformable complex, composed of calcium alginate (CaAlg) hydrogel shell and Zeolitic imidazolate framework-8 (ZIF-8) core encapsulating Glucose oxidase (GOx)/Catalase (CAT) and Minocycline (MINO), named as CaAlg@MINO/GOx/CAT/ZIF-8 (CMGCZ). The reaction product of glucose-scavenging, gluconic acid, could dissolve ZIF-8 core and transform CMGCZ from inflexible to flexible, facilitating the complex to overcome the diffusion-reaction inhibition of biofilm. Meanwhile, reduced glucose concentration could ameliorate the pyroptosis of macrophages to decrease the secretion of pro-inflammatory factors, thereby reducing inflamm-aging to alleviate periodontal dysfunction. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2590-0064 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2590006423001382; https://doaj.org/toc/2590-0064 |
| DOI: | 10.1016/j.mtbio.2023.100678 |
| URL الوصول: | https://doaj.org/article/5da965a55a62439fb8c1679203c5f9ae |
| رقم الانضمام: | edsdoj.5da965a55a62439fb8c1679203c5f9ae |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 25900064 |
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| DOI: | 10.1016/j.mtbio.2023.100678 |