التفاصيل البيبلوغرافية
| العنوان: |
Efficacy of erlotinib in NSCLC harboring rare EGFR extracellular domain mutation (T263P) and common mutations: Case report and literature review |
| المؤلفون: |
Qian Wang, Yong Wang, Xinwei Zhang, Chen Fang, Xiaoying Qian, Yong Li |
| المصدر: |
Frontiers in Oncology, Vol 12 (2022) |
| بيانات النشر: |
Frontiers Media S.A., 2022. |
| سنة النشر: |
2022 |
| المجموعة: |
LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: |
EGFR extracellular domain mutations, exon 7 T263P mutation, tyrosine kinase inhibitors, erlotinib (ELTN), adenocarcinoma of the lung, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: |
The epidermal growth factor receptor (EGFR) typically contains an extracellular domain (ECD), a transmembrane (TM) domain, and an intracellular kinase (KD) domain. ECD mutations of EGFR in NSCLC may affect its normal function and intrinsic resistance to tyrosine kinase inhibitors (TKIs) and the effectiveness of drugs for these patients is unsatisfactory. Recently, we found an EGFR T263P mutation located at the ECD, which has never been reported in Chinese non-small cell lung cancer (NSCLC). Hence, we reported that a patient with advanced lung adenocarcinoma harboring the EGFR T263P mutation, L858R mutation and MET amplification was resistant to osimertinib but significantly benefited from erlotinib and capmatinib treatment. This patient achieved a partial response and had progression-free survival (PFS) for more than 19 months. In summary, we are the first researchers to report in detail on a Chinese patient carrying the T263P mutation and summarize all the ECD mutations in NSCLC. We believe this finding will enlighten us to treat patients with EGFR ECD mutations and more patients deserve further study. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2234-943X |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fonc.2022.954026/full; https://doaj.org/toc/2234-943X |
| DOI: |
10.3389/fonc.2022.954026 |
| URL الوصول: |
https://doaj.org/article/ca5d9682dc47436ca34e71da71c6d684 |
| رقم الانضمام: |
edsdoj.5d9682dc47436ca34e71da71c6d684 |
| قاعدة البيانات: |
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