Academic Journal
Sex differences evident in elevated anxiety symptoms in multiple sclerosis, inflammatory bowel disease, and rheumatoid arthritis
| العنوان: | Sex differences evident in elevated anxiety symptoms in multiple sclerosis, inflammatory bowel disease, and rheumatoid arthritis |
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| المؤلفون: | Jerlin Joyees, Ruth Ann Marrie, Charles N. Bernstein, James M. Bolton, John D. Fisk, Lesley A. Graff, Carol Hitchon, Scott B. Patten, Kaarina Kowalec, for the CIHR team in defining the burden and managing the effects of psychiatric comorbidity in chronic immunoinflammatory disease, Lesley Graff, John R. Walker, Carol A. Hitchon, Lisa M. Lix, James Bolton, Jitender Sareen, Alan Katz, James J. Marriott, Alexander Singer, Renée El-Gabalawy, Christine A. Peschken, Ryan Zarychanski, Lindsay I. Berrigan |
| المصدر: | Frontiers in Psychiatry, Vol 14 (2023) |
| بيانات النشر: | Frontiers Media S.A., 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Psychiatry |
| مصطلحات موضوعية: | anxiety, sex, immune-mediated inflammatory disease, multiple sclerosis, rheumatoid arthritis, inflammatory bowel disease, Psychiatry, RC435-571 |
| الوصف: | IntroductionImmune-mediated inflammatory diseases (IMID), such as multiple sclerosis (MS), inflammatory bowel disease (IBD) or rheumatoid arthritis (RA) have high rates of elevated anxiety symptoms. This can may worsen functioning and increase IMID disease burden. The rate of and factors associated with elevated anxiety symptoms may differ between males and females, which, in turn can affect diagnosis and disease management. We evaluated whether the frequency and factors associated with comorbid elevated anxiety symptoms in those with an IMID differed by sex.MethodsParticipants with an IMID (MS, IBD or RA) completed two anxiety measures (HADS, GAD-7). We used logistic regression to investigate whether sex differences exist in the presence of comorbid elevated anxiety symptoms or in the endorsement of individual anxiety items in those with an IMID.ResultsOf 656 participants, females with an IMID were more likely to have elevated anxiety symptoms compared to males (adjusted odds ratio [aOR] 2.05; 95%CI: 1.2, 3.6). Younger age, higher depressive symptoms and income were also associated with elevated anxiety symptoms in IMID. Lower income in males with an IMID, but not females, was associated with elevated anxiety symptoms (aOR: 4.8; 95%CI: 1.5, 15.6). No other factors demonstrated a sex difference. Males had nearly twice the odds of endorsing restlessness on the GAD-7 (OR = 1.8, 95%CI: 1.07, 3.15) compared to females.DiscussionWe found evidence for sex differences in the factors associated with experiencing elevated anxiety symptoms in those with an IMID. These findings could be helpful to sensitize clinicians to monitor for comorbid anxiety symptoms in males with an IMID. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1664-0640 74724762 |
| Relation: | https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1260420/full; https://doaj.org/toc/1664-0640 |
| DOI: | 10.3389/fpsyt.2023.1260420 |
| URL الوصول: | https://doaj.org/article/5d7f536b74724762b181c211f757311b |
| رقم الانضمام: | edsdoj.5d7f536b74724762b181c211f757311b |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 16640640 74724762 |
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| DOI: | 10.3389/fpsyt.2023.1260420 |