Academic Journal

Diagnosis of complication in lung transplantation by TBLB + ROSE + mNGS

التفاصيل البيبلوغرافية
العنوان: Diagnosis of complication in lung transplantation by TBLB + ROSE + mNGS
المؤلفون: Wang Qing, Feng Jing, Zhang Ji, Shi Lingzhi, Jin Zhixian, Liu Dong, Wu Bo, Chen Jingyu
المصدر: Open Medicine, Vol 15, Iss 1, Pp 968-980 (2020)
بيانات النشر: De Gruyter, 2020.
سنة النشر: 2020
المجموعة: LCC:Medicine
مصطلحات موضوعية: lung transplantation, infection, complication, transbronchial lung biopsy, rapid on-site cytological evaluation, metagenomic next-generation sequencing, Medicine
الوصف: Lung transplantation is a potentially life-saving therapy for patients with terminal respiratory illnesses. Long-term survival is limited by the development of a variety of opportunistic infections and rejection. Optimal means of differential diagnosis of infection and rejection have not been established. With these challenges in mind, we tried to use transbronchial lung biopsy (TBLB) rapid on-site cytological evaluation (ROSE), metagenomic next-generation sequencing (mNGS), and routine histologic examination to timely distinguish infection and rejection, and accurately detect etiologic pathogens. We reviewed the medical records of all patients diagnosed with infection or rejection by these means from December 2017 to September 2018 in our center. We identified seven recipients whose clinical course was complicated by infection or rejection. Three patients were diagnosed with acute rejection, organizing pneumonia, and acute fibrinoid organizing pneumonia, respectively. Four of the seven patients were diagnosed with infections, including Pneumocystis carinii pneumonia, cytomegalovirus, Aspergillus, and bacterial pneumonia. These patients recovered after proper treatment. TBLB + ROSE + mNGS might be a good method to accurately detect etiologic pathogens, which may help us to facilitate the use of targeted and precision medicine therapy in postoperative complications and avoid unnecessary potential adverse effects of drugs.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2391-5463
Relation: http://www.degruyter.com/view/j/med.2020.15.issue-1/med-2020-0232/med-2020-0232.xml?format=INT; https://doaj.org/toc/2391-5463
DOI: 10.1515/med-2020-0232
URL الوصول: https://doaj.org/article/e5d2b24e87a3434dbe500074a21bbab6
رقم الانضمام: edsdoj.5d2b24e87a3434dbe500074a21bbab6
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:23915463
DOI:10.1515/med-2020-0232