التفاصيل البيبلوغرافية
| العنوان: |
Antiobesity and antihyperlipidaemic effects of Yan-Sheng-Yin in animals and humans |
| المؤلفون: |
Chi-Han Wu, Chun-Hsu Pan, Ching-Kuo Lee, Ming-Jyh Sheu, Fon-Chang Liu, Guei-Jane Wang, Chieh-Hsi Wu |
| المصدر: |
Journal of Functional Foods, Vol 24, Iss , Pp 173-182 (2016) |
| بيانات النشر: |
Elsevier, 2016. |
| سنة النشر: |
2016 |
| المجموعة: |
LCC:Nutrition. Foods and food supply |
| مصطلحات موضوعية: |
Adipocyte differentiation, Atherogenesis, Hyperlipidaemia, Obesity, Yan-Sheng-Yin, Nutrition. Foods and food supply, TX341-641 |
| الوصف: |
Yan-Sheng-Yin (YSY), a Chinese natural dietary supplement that promotes good health, is entirely composed of natural foods. Whether YSY is a potential adjuvant intervention for reducing hyperlipidaemia, atherogenesis, or obesity is unclear. This study evaluated the inhibitory effects and mechanisms of YSY for hyperlipidaemia, atherogenesis, and obesity. Experimental results showed that YSY reduced body weight, hyperlipidaemia, fatty liver, and atherogenesis in hyperlipidaemic mice. In addition, YSY promoted lipid metabolism by inducing adiponectin secretion and activation (phosphorylation) of 5′ adenosine monophosphate-activated protein kinase (AMPK) and by suppressing the activation of acetyl-CoA carboxylase (ACC) and HMG-CoA reductase (HMGCR). Moreover, YSY inhibited adipocyte differentiation by suppressing peroxisome proliferator-activated receptor gamma (PPAR-γ) and CCAAT/enhancer-binding proteins (C/EBPs). Furthermore, the antihyperlipidaemic effect of YSY was observed in the clinical trial. Our findings suggest that YSY is an adjuvant intervention for treating and preventing hyperlipidaemia, atherogenesis, and obesity. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1756-4646 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S1756464616300585; https://doaj.org/toc/1756-4646 |
| DOI: |
10.1016/j.jff.2016.04.004 |
| URL الوصول: |
https://doaj.org/article/5c816e9b48fd46a39652fa3cb095db41 |
| رقم الانضمام: |
edsdoj.5c816e9b48fd46a39652fa3cb095db41 |
| قاعدة البيانات: |
Directory of Open Access Journals |