Academic Journal
Chitosan-PEG Gels Loaded with Jatropha mollissima (Pohl) Baill. Ethanolic Extract: An Efficient and Effective Biomaterial in Hemorrhage Control
| العنوان: | Chitosan-PEG Gels Loaded with Jatropha mollissima (Pohl) Baill. Ethanolic Extract: An Efficient and Effective Biomaterial in Hemorrhage Control |
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| المؤلفون: | José F. B. Rodrigues, João V. S. de A. Queiroz, Rebeca P. Medeiros, Rafaela O. Santos, Djair A. Fialho, João E. S. Neto, Rogério L. dos Santos, Rossemberg C. Barbosa, Wladymyr J. B. Sousa, Maria da C. de M. Torres, Luanna A. D. M. Medeiros, Suédina M. de L. Silva, Maziar Montazerian, Marcus V. L. Fook, Solomon K. S. Amoah |
| المصدر: | Pharmaceuticals, Vol 16, Iss 10, p 1399 (2023) |
| بيانات النشر: | MDPI AG, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Medicine LCC:Pharmacy and materia medica |
| مصطلحات موضوعية: | chitosan, plant extracts, injuries, bleeding, biomaterials, hemostasis, Medicine, Pharmacy and materia medica, RS1-441 |
| الوصف: | A lack of control over blood loss can have catastrophic implications, including death. Although several hemostatic medications have been employed to reduce bleeding, a vast majority of them are ineffective, expensive, or pose health risks to the patient. To overcome these constraints, chitosan-polyethylene glycol (CS-PEG) hemostatic gels loaded with ethanolic extract of Jatropha mollissima sap (EES) were prepared and their hemostatic, physicochemical, and cytotoxic properties were evaluated. The gels were produced by mixing CS with PEG (an external plasticizer) and EES. The phytochemical analysis revealed a significant concentration of total polyphenols and tannins content in the extract and catechin was identified as one of the key compounds of EES. Infrared spectroscopy analysis revealed the presence of EES in the gels, as well as the chemical interaction between CS and PEG. The gels were thermally stable between 25 and 37 °C (ambient and human body temperature range), had pseudoplastic deformation behavior (rheological properties preserved after shearing), were simple to inject (compression force 30 N), and were biocompatible. In vivo experiments showed that both CS-PEG-EES gels exhibited greater hemostatic action in preventing tail hemorrhage in Wistar rats, with decreased bleeding time and blood weight compared with unloaded CS-PEG gels (control groups) and Hemostank, a commercial product. However, the gel prepared with acetic acid was more efficient in controlling bleeding. These findings reveal that CS-PEG-EES gels can reduce hemorrhages and are a potent, simple, and safe hemostatic agent. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1424-8247 |
| Relation: | https://www.mdpi.com/1424-8247/16/10/1399; https://doaj.org/toc/1424-8247 |
| DOI: | 10.3390/ph16101399 |
| URL الوصول: | https://doaj.org/article/a5c4e85a11224aa19ed210e7406175de |
| رقم الانضمام: | edsdoj.5c4e85a11224aa19ed210e7406175de |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14248247 |
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| DOI: | 10.3390/ph16101399 |