التفاصيل البيبلوغرافية
| العنوان: |
Advancements in MRSA treatment: the role of berberine in enhancing antibiotic therapy |
| المؤلفون: |
Fangfang Zhou, Xuemei Gu, Wei Wang, Ming Lin, Lei Wang |
| المصدر: |
BMC Microbiology, Vol 24, Iss 1, Pp 1-12 (2024) |
| بيانات النشر: |
BMC, 2024. |
| سنة النشر: |
2024 |
| المجموعة: |
LCC:Microbiology |
| مصطلحات موضوعية: |
Berberine, Methicillin-resistant Staphylococcus aureus, Minimum inhibitory concentration, Network pharmacology, Cell wall damage, Microbiology, QR1-502 |
| الوصف: |
Abstract Background Methicillin-resistant Staphylococcus aureus (MRSA) is a significant public health problem. This study investigated the antimicrobial properties and mechanisms of berberine (BBR), a plant alkaloid, against MRSA, evaluating its potential to enhance antibiotic therapy. Results Berberine only demonstrated variable but significant inhibitory effects on 50 clinical MRSA strains. When combined with antibiotics, synergistic effects were observed only with amikacin in 6 of the 50 MRSA strains. BBR disrupted MRSA cell wall integrity, leading to leakage of cellular contents. Network pharmacology analysis revealed that BBR targets multiple pathways essential for bacterial survival. Conclusion The study confirmed the potent antimicrobial activity of berberine against MRSA and its capability to act synergistically with traditional antibiotics. Berberine’s impact on cell wall integrity and bacterial survival pathways highlights its potential as an adjunct therapy in MRSA treatment. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1471-2180 |
| Relation: |
https://doaj.org/toc/1471-2180 |
| DOI: |
10.1186/s12866-024-03692-9 |
| URL الوصول: |
https://doaj.org/article/5b456cafbe0e41bcab75290a27b8f798 |
| رقم الانضمام: |
edsdoj.5b456cafbe0e41bcab75290a27b8f798 |
| قاعدة البيانات: |
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