Academic Journal
Antibacterial and Anti-Influenza Activities of N-Heterocyclic Carbene–Gold Complexes
| العنوان: | Antibacterial and Anti-Influenza Activities of N-Heterocyclic Carbene–Gold Complexes |
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| المؤلفون: | Michele Pellegrino, Paola Checconi, Jessica Ceramella, Carla Prezioso, Dolores Limongi, Maria Marra, Annaluisa Mariconda, Alessia Catalano, Marta De Angelis, Lucia Nencioni, Maria Stefania Sinicropi, Pasquale Longo, Stefano Aquaro |
| المصدر: | Pharmaceuticals, Vol 17, Iss 12, p 1680 (2024) |
| بيانات النشر: | MDPI AG, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Medicine LCC:Pharmacy and materia medica |
| مصطلحات موضوعية: | antimicrobials, influenza virus, drug resistance, N-heterocyclic carbene–gold complexes, metal-based therapeutics, Medicine, Pharmacy and materia medica, RS1-441 |
| الوصف: | Background/Objectives: Infectious diseases represent a serious threat due to rising antimicrobial resistance, particularly among multidrug-resistant bacteria and influenza viruses. Metal-based complexes, such as N-heterocyclic carbene–gold (NHC–gold) complexes, show promising therapeutic potential due to their ability to inhibit various pathogens. Methods: Eight NHC–gold complexes were synthesized and tested for antibacterial activity against Escherichia coli, Enterococcus faecalis, Staphylococcus aureus, and for anti-influenza activity in lung and bronchial epithelial cells infected with influenza virus A/H1N1. Antibacterial activity was assessed through the determination of the minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC), while the viral load was quantified using qRT-PCR. Results: Complexes 3, 4, and 6 showed significant antibacterial activity at concentrations of 10–20 µg/mL. Additionally, these complexes significantly reduced viral load, with complexes 3 and 4 markedly inhibiting replication. Conclusions: These findings support the potential use of NHC–gold complexes in combined antimicrobial and antiviral therapies, representing an attractive option for fighting resistant infections. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1424-8247 |
| Relation: | https://www.mdpi.com/1424-8247/17/12/1680; https://doaj.org/toc/1424-8247 |
| DOI: | 10.3390/ph17121680 |
| URL الوصول: | https://doaj.org/article/5af9b6d09a9343d69880ef7f4004afe1 |
| رقم الانضمام: | edsdoj.5af9b6d09a9343d69880ef7f4004afe1 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14248247 |
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| DOI: | 10.3390/ph17121680 |