Academic Journal
D-Dimer Levels as a Predictive Marker of Pulmonary Embolism in COVID-19 Patients
| العنوان: | D-Dimer Levels as a Predictive Marker of Pulmonary Embolism in COVID-19 Patients |
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| المؤلفون: | Namirah Iftikhar, Osama Rehman Khalid, Asif Husain Osmani, Uzma Ghori, Ashar Ekhlaq Ahmed |
| المصدر: | Pakistan Journal of Medicine and Dentistry, Vol 13, Iss 3 (2024) |
| بيانات النشر: | ziauddin University, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Biochemistry LCC:Dentistry LCC:Therapeutics. Pharmacology LCC:Medicine (General) |
| مصطلحات موضوعية: | Coronavirus Disease 2019, Thromboembolisms, Pulmonary, D-dimer., Biochemistry, QD415-436, Dentistry, RK1-715, Therapeutics. Pharmacology, RM1-950, Medicine (General), R5-920 |
| الوصف: | Background: COVID-19 infections have a higher risk of thrombotic complications due to a pro-inflammatory environment. This study aimed to find the association of D-dimer levels with pulmonary embolism (PE) and assess D-dimer levels as a predictive marker of PE in COVID-19 patients. Methods: This prospective cross-sectional study was conducted from June to December 2021, at a private tertiary care teaching hospital in Karachi. Hospitalized COVID-19 patients with CTPA for PE, aged ≥18 years were selected through purposive sampling. With SPSS v.21, the association of co-morbidities and D-dimer levels for pulmonary embolism was analyzed using a t-test, chi-square test, and regression analysis while the predictive value of D-dimer levels for pulmonary embolism was analyzed using ROC analysis. Results: Participants (337), median age:50yrs, IQR:48-70(52.2% males, 47.8% females). The majority (96.7%) were receiving prophylactic anticoagulant therapy, Median D-dimer levels were 1380(IQR:800-2100). Pulmonary Embolism was found in 46(13.6%), had a significant association with disease duration >5days (p=0.01), D-dimer levels >2200(p2285ng/ml have 80% diagnostic accuracy for pulmonary embolism. Larger multicentre studies are warranted to explore thrombo-prophylaxis indications, drug choice, and dosing based on D-dimer levels. Keywords: COVID-19, Thromboembolism, Pulmonary, D-dimer |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2313-7371 2308-2593 |
| Relation: | https://ojs.zu.edu.pk/pjmd/article/view/2538; https://doaj.org/toc/2313-7371; https://doaj.org/toc/2308-2593 |
| DOI: | 10.36283/PJMD13-3/011 |
| URL الوصول: | https://doaj.org/article/5af4581b94944e42a7762ebbcf833a9e |
| رقم الانضمام: | edsdoj.5af4581b94944e42a7762ebbcf833a9e |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 23137371 23082593 |
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| DOI: | 10.36283/PJMD13-3/011 |