Academic Journal
ADALIMUMAB FOR MAINTENANCE THERAPY FOR ONE YEAR IN CROHN?S DISEASE: results of a Latin American single-center observational study
| العنوان: | ADALIMUMAB FOR MAINTENANCE THERAPY FOR ONE YEAR IN CROHN?S DISEASE: results of a Latin American single-center observational study |
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| المؤلفون: | Paulo Gustavo KOTZE, Vinícius Rezende ABOU-REJAILE, Luciana Aparecida UIEMA, Marcia OLANDOSKI, Maria Cristina SARTOR, Eron Fábio MIRANDA, Lorete Maria da Silva KOTZE, Rogério SAAD-HOSSNE |
| المصدر: | Arquivos de Gastroenterologia, Vol 51, Iss 1, Pp 39-45 (2014) |
| بيانات النشر: | Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia (IBEPEGE), 2014. |
| سنة النشر: | 2014 |
| المجموعة: | LCC:Diseases of the digestive system. Gastroenterology |
| مصطلحات موضوعية: | Fator de necrose tumoral alfa, Antagonistas adrenérgicos alfa, administração e dosagem, Doença de Crohn, prevenção e controle, Diseases of the digestive system. Gastroenterology, RC799-869 |
| الوصف: | Context Adalimumab is a fully-human antibody that inhibits TNF alpha, with a significant efficacy for long-term maintenance of remission. Studies with this agent in Latin American Crohn’s disease patients are scarce. Objectives The objective of this study was to outline clinical remission rates after 12 months of adalimumab therapy for Crohn’s disease patients. Methods Retrospective, single-center, observational study of a Brazilian case series of Crohn’s disease patients under adalimumab therapy. Variables analyzed: demographic data, Montreal classification, concomitant medication, remission rates after 1, 4, 6 and 12 months. Remission was defined as Harvey-Bradshaw Index ≤4, and non-responder-imputation and last-observation-carried-forward analysis were used. The influence of infliximab on remission rates was analyzed by Fischer and Chi-square tests (P |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1678-4219 0004-2803 |
| Relation: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28032014000100039&lng=en&tlng=en; https://doaj.org/toc/1678-4219 |
| DOI: | 10.1590/S0004-28032014000100009 |
| URL الوصول: | https://doaj.org/article/59c72e106ec9488ca7fe242f38fb1eff |
| رقم الانضمام: | edsdoj.59c72e106ec9488ca7fe242f38fb1eff |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 16784219 00042803 |
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| DOI: | 10.1590/S0004-28032014000100009 |