Academic Journal
β-Carotene accelerates the resolution of atherosclerosis in mice
| العنوان: | β-Carotene accelerates the resolution of atherosclerosis in mice |
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| المؤلفون: | Ivan Pinos, Johana Coronel, Asma'a Albakri, Amparo Blanco, Patrick McQueen, Donald Molina, JaeYoung Sim, Edward A Fisher, Jaume Amengual |
| المصدر: | eLife, Vol 12 (2024) |
| بيانات النشر: | eLife Sciences Publications Ltd, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Medicine LCC:Science LCC:Biology (General) |
| مصطلحات موضوعية: | retinoic acid, forkhead box P3, inflammation, FoxP3, Medicine, Science, Biology (General), QH301-705.5 |
| الوصف: | β-Carotene oxygenase 1 (BCO1) catalyzes the cleavage of β-carotene to form vitamin A. Besides its role in vision, vitamin A regulates the expression of genes involved in lipid metabolism and immune cell differentiation. BCO1 activity is associated with the reduction of plasma cholesterol in humans and mice, while dietary β-carotene reduces hepatic lipid secretion and delays atherosclerosis progression in various experimental models. Here we show that β-carotene also accelerates atherosclerosis resolution in two independent murine models, independently of changes in body weight gain or plasma lipid profile. Experiments in Bco1-/- mice implicate vitamin A production in the effects of β-carotene on atherosclerosis resolution. To explore the direct implication of dietary β-carotene on regulatory T cells (Tregs) differentiation, we utilized anti-CD25 monoclonal antibody infusions. Our data show that β-carotene favors Treg expansion in the plaque, and that the partial inhibition of Tregs mitigates the effect of β-carotene on atherosclerosis resolution. Our data highlight the potential of β-carotene and BCO1 activity in the resolution of atherosclerotic cardiovascular disease. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2050-084X |
| Relation: | https://elifesciences.org/articles/87430; https://doaj.org/toc/2050-084X |
| DOI: | 10.7554/eLife.87430 |
| URL الوصول: | https://doaj.org/article/592da35d226e4012b20799dc36c9152a |
| رقم الانضمام: | edsdoj.592da35d226e4012b20799dc36c9152a |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 2050084X |
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| DOI: | 10.7554/eLife.87430 |