التفاصيل البيبلوغرافية
| العنوان: |
Overexpression of Bmp4 induces microphthalmia by disrupting embryonic neural retina |
| المؤلفون: |
Baige Li, Zeyuan Pu, Keren Liao, Yuxin Du, Gao Tan, Scott Nawy, Shiqiang Gao, Yin Shen |
| المصدر: |
Neurobiology of Disease, Vol 201, Iss , Pp 106654- (2024) |
| بيانات النشر: |
Elsevier, 2024. |
| سنة النشر: |
2024 |
| المجموعة: |
LCC:Neurosciences. Biological psychiatry. Neuropsychiatry |
| مصطلحات موضوعية: |
Microphthalmia, Bmp4, Retina, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571 |
| الوصف: |
Microphthalmia, mostly an autosomal dominant disorder, is a worldwide severe congenital ocular malformation that causes visual impairment. Our investigation unveiled a total of 30 genes associated with microphthalmia. Employing the CytoHubba and PPI network, we identified Bmp4 as the most pivotal hub gene. Subsequently, the conditional overexpression of Bmp4 in the retina caused highly distinctive microphthalmia, manifested by retinal disorganization with ganglion cell misalignment. Significant reduction in the number and abnormal distribution location of retinal cells in microphthalmia model mice. Elevated Bmp4 was associated with an increase in retinal apoptosis and a decrease in proliferating cells, which exacerbates the development of microphthalmia. Here we identify Bmp4 as an extremely important gene responsible for microphthalmia and the involved mechanisms. Overexpression of Bmp4 induces retinal cell ectopic expression and developmental defects, highlighting the importance of a well-balanced Bmp4 level in shaping the embryonic retina during early development. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1095-953X |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S0969996124002547; https://doaj.org/toc/1095-953X |
| DOI: |
10.1016/j.nbd.2024.106654 |
| URL الوصول: |
https://doaj.org/article/5863910e798a4fb192ccc45ec74bb133 |
| رقم الانضمام: |
edsdoj.5863910e798a4fb192ccc45ec74bb133 |
| قاعدة البيانات: |
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