Academic Journal
Association of miR-144 levels in the peripheral blood with COVID-19 severity and mortality
| العنوان: | Association of miR-144 levels in the peripheral blood with COVID-19 severity and mortality |
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| المؤلفون: | Alisia Madè, Simona Greco, Melanie Vausort, Marios Miliotis, Eric Schordan, Shounak Baksi, Lu Zhang, Ekaterina Baryshnikova, Marco Ranucci, Rosanna Cardani, Guy Fagherazzi, Markus Ollert, Spyros Tastsoglou, Giannis Vatsellas, Artemis Hatzigeorgiou, Hüseyin Firat, Yvan Devaux, Fabio Martelli |
| المصدر: | Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022) |
| بيانات النشر: | Nature Portfolio, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Medicine, Science |
| الوصف: | Abstract Coronavirus disease-2019 (COVID-19) can be asymptomatic or lead to a wide symptom spectrum, including multi-organ damage and death. Here, we explored the potential of microRNAs in delineating patient condition and predicting clinical outcome. Plasma microRNA profiling of hospitalized COVID-19 patients showed that miR-144-3p was dynamically regulated in response to COVID-19. Thus, we further investigated the biomarker potential of miR-144-3p measured at admission in 179 COVID-19 patients and 29 healthy controls recruited in three centers. In hospitalized patients, circulating miR-144-3p levels discriminated between non-critical and critical illness (AUCmiR-144-3p = 0.71; p = 0.0006), acting also as mortality predictor (AUCmiR-144-3p = 0.67; p = 0.004). In non-hospitalized patients, plasma miR-144-3p levels discriminated mild from moderate disease (AUCmiR-144-3p = 0.67; p = 0.03). Uncontrolled release of pro-inflammatory cytokines can lead to clinical deterioration. Thus, we explored the added value of a miR-144/cytokine combined analysis in the assessment of hospitalized COVID-19 patients. A miR-144-3p/Epidermal Growth Factor (EGF) combined score discriminated between non-critical and critical hospitalized patients (AUCmiR-144-3p/EGF = 0.81; p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2045-2322 |
| Relation: | https://doaj.org/toc/2045-2322 |
| DOI: | 10.1038/s41598-022-23922-2 |
| URL الوصول: | https://doaj.org/article/584c3cc3aee14265a60c9afbce43330e |
| رقم الانضمام: | edsdoj.584c3cc3aee14265a60c9afbce43330e |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20452322 |
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| DOI: | 10.1038/s41598-022-23922-2 |