Academic Journal
The reduction of aorta histopathological images through inhibition of reactive oxygen species formation in hypercholesterolemia rattus norvegicus treated with polysaccharide peptide of Ganoderma lucidum
| العنوان: | The reduction of aorta histopathological images through inhibition of reactive oxygen species formation in hypercholesterolemia rattus norvegicus treated with polysaccharide peptide of Ganoderma lucidum |
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| المؤلفون: | Titin Andri Wihastuti, Djanggan Sargowo, Teuku Heriansyah, Yasmin Eka Aziza, Dyah Puspitarini, Amalina Nur Iwana, Lucky Astrida Evitasari |
| المصدر: | Iranian Journal of Basic Medical Sciences, Vol 18, Iss 5, Pp 514-519 (2015) |
| بيانات النشر: | Mashhad University of Medical Sciences, 2015. |
| سنة النشر: | 2015 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | Atherosclerosis, Atherosclerotic plaque, Foam cells, Ganoderma lucidum, Hydrogen peroxide, Polysaccharide peptide, Perivascular vascular adipose - tissue, Medicine |
| الوصف: | Objective(s):Atherosclerosis is chronic inflammatory process triggered by oxidative stress. Oxidative stress can increase hydrogen peroxide (H2O2)level, which induce atherosclerosis through the processes such as formation of perivascular adipose tissue (PVAT), foam cells, and atherosclerotic plaque. Antioxidant is needed to control negative effects of oxidative stress. One source of antioxidant, which has potential to be developed, is PsP from Ganoderma lucidum. This study aims to prove the effect of PsP in decreasing H2O2, PVAT, foam cells and atherosclerotic plaque. Materials and Methods: This study was experimental randomized post-test with control group design using 25 Rattus norvegicus Wistar strain rats. Rats were divided into 5 groups (negative control, positive control, and 3 high-fat diet group with PsP dose: 50, 150, 300 mg/kgBW). Measured parameters were H2O2, PVAT, foam cell, and atherosclerotic plaques. Analysis of variance (ANOVA) was used for statistical analysis, followed by post hoc test. Results: Mean H2O2 levels, PVAT thickness, foam cell numbers, and atherosclerotic plaque were low in negative control group. ANOVA showed that PsP significantly (P |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2008-3866 2008-3874 |
| Relation: | http://ijbms.mums.ac.ir/pdf_4416_074a500871915f4b5b0d8d2dc5904258.html; https://doaj.org/toc/2008-3866; https://doaj.org/toc/2008-3874 |
| URL الوصول: | https://doaj.org/article/583dc7603f3a4bef8ac1cddc86a551e9 |
| رقم الانضمام: | edsdoj.583dc7603f3a4bef8ac1cddc86a551e9 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20083866 20083874 |
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