التفاصيل البيبلوغرافية
| العنوان: |
A new indolocarbazole derivative in melanoma and carcinoma lung in vivo treatment |
| المؤلفون: |
Anna Lantsova, Irina Golubeva, Larisa Borisova, Lyudmila Nikolaeva, Lydia Ektova, Maria Dmitrieva, Olga Orlova |
| المصدر: |
BMC Complementary Medicine and Therapies, Vol 21, Iss 1, Pp 1-8 (2021) |
| بيانات النشر: |
BMC, 2021. |
| سنة النشر: |
2021 |
| المجموعة: |
LCC:Other systems of medicine |
| مصطلحات موضوعية: |
Indolocarbazole derivatives, Antitumor activity, Inhibitor, Vasculogenic mimicry, Topoisomerase, Angiogenesis, Other systems of medicine, RZ201-999 |
| الوصف: |
Abstract Objective The current scientific research direction is development of drugs with a targeted effect on malignant tumors. One of the promising groups is indolocarbazoles and their derivatives, which can initiate various tumor cell death pathways. Russian scientists from N. N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of Russian Federation has developed a new experimental drug form of the original compound LCS 1269 with cytotoxic and antiangiogenic properties, blocking vasculogenic mimicry in tumor. The study aim is the experimental drug form LCS 1269 antitumor activity on models of transplantable mouse tumors B-16 melanoma and Lewis epidermoid lung carcinoma (LLC) with different routes and modes of administration. Material and methods Female F1 hybrid mice (C57Bl/6 x DBA/2) and male and female linear mice C57BL/6 were used for management of tumor strains. Mice were obtained from N. N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of Russian Federation vivarium. The antitumor effect was assessed by tumor growth inhibition (TGI) and increase of treated animal’s life span (ILS) compared to the control. Results The experimental drug form showed high antitumor activity when administered intravenously once at doses of 100 and 120 mg/kg (TGI = 98–82% and TGI = 95–77%, respectively, ILS = 24%, p |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2662-7671 |
| Relation: |
https://doaj.org/toc/2662-7671 |
| DOI: |
10.1186/s12906-021-03294-2 |
| URL الوصول: |
https://doaj.org/article/d579c32b5eff4047b1aacab371ae33b5 |
| رقم الانضمام: |
edsdoj.579c32b5eff4047b1aacab371ae33b5 |
| قاعدة البيانات: |
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