التفاصيل البيبلوغرافية
| العنوان: |
Endogenous neural stem cells characterization using omics approaches: Current knowledge in health and disease |
| المؤلفون: |
Valentina Murtaj, Erica Butti, Gianvito Martino, Paola Panina-Bordignon |
| المصدر: |
Frontiers in Cellular Neuroscience, Vol 17 (2023) |
| بيانات النشر: |
Frontiers Media S.A., 2023. |
| سنة النشر: |
2023 |
| المجموعة: |
LCC:Neurosciences. Biological psychiatry. Neuropsychiatry |
| مصطلحات موضوعية: |
neural stem cells, SVZ (subventricular zone), omics, neurodegeneration, transciptome analysis, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571 |
| الوصف: |
Neural stem cells (NSCs), an invaluable source of neuronal and glial progeny, have been widely interrogated in the last twenty years, mainly to understand their therapeutic potential. Most of the studies were performed with cells derived from pluripotent stem cells of either rodents or humans, and have mainly focused on their potential in regenerative medicine. High-throughput omics technologies, such as transcriptomics, epigenetics, proteomics, and metabolomics, which exploded in the past decade, represent a powerful tool to investigate the molecular mechanisms characterizing the heterogeneity of endogenous NSCs. The transition from bulk studies to single cell approaches brought significant insights by revealing complex system phenotypes, from the molecular to the organism level. Here, we will discuss the current literature that has been greatly enriched in the “omics era”, successfully exploring the nature and function of endogenous NSCs and the process of neurogenesis. Overall, the information obtained from omics studies of endogenous NSCs provides a sharper picture of NSCs function during neurodevelopment in healthy and in perturbed environments. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1662-5102 |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fncel.2023.1125785/full; https://doaj.org/toc/1662-5102 |
| DOI: |
10.3389/fncel.2023.1125785 |
| URL الوصول: |
https://doaj.org/article/56ce6650dd1c4f9cae1b4fc30b79f03b |
| رقم الانضمام: |
edsdoj.56ce6650dd1c4f9cae1b4fc30b79f03b |
| قاعدة البيانات: |
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