Academic Journal
COVID-19 Infection and Myocarditis: A State-of-the-Art Systematic Review
| العنوان: | COVID-19 Infection and Myocarditis: A State-of-the-Art Systematic Review |
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| المؤلفون: | Vikash Jaiswal, Zouina Sarfraz, Azza Sarfraz, Dattatreya Mukherjee, Nitya Batra, Gazala Hitawala, Sadia Yaqoob, Abhinav Patel, Preeti Agarwala, Ruchika, Muzna Sarfraz, Shehar Bano, Nishwa Azeem, Sidra Naz, Akash Jaiswal, Prachi Sharma, Gaurav Chaudhary |
| المصدر: | Journal of Primary Care & Community Health, Vol 12 (2021) |
| بيانات النشر: | SAGE Publishing, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Computer applications to medicine. Medical informatics LCC:Public aspects of medicine |
| مصطلحات موضوعية: | Computer applications to medicine. Medical informatics, R858-859.7, Public aspects of medicine, RA1-1270 |
| الوصف: | Background: COVID-19 was initially considered to be a respiratory illness, but current findings suggest that SARS-CoV-2 is increasingly expressed in cardiac myocytes as well. COVID-19 may lead to cardiovascular injuries, resulting in myocarditis, with inflammation of the heart muscle. Objective: This systematic review collates current evidence about demographics, symptomatology, diagnostic, and clinical outcomes of COVID-19 infected patients with myocarditis. Methods: In accordance with PRISMA 2020 guidelines, a systematic search was conducted using PubMed, Cochrane Central, Web of Science and Google Scholar until August, 2021. A combination of the following keywords was used: SARS-CoV-2, COVID-19, myocarditis. Cohorts and case reports that comprised of patients with confirmed myocarditis due to COVID-19 infection, aged >18 years were included. The findings were tabulated and subsequently synthesized. Results: In total, 54 case reports and 5 cohorts were identified comprising 215 patients. Hypertension (51.7%), diabetes mellitus type 2 (46.4%), cardiac comorbidities (14.6%) were the 3 most reported comorbidities. Majority of the patients presented with cough (61.9%), fever (60.4%), shortness of breath (53.2%), and chest pain (43.9%). Inflammatory markers were raised in 97.8% patients, whereas cardiac markers were elevated in 94.8% of the included patients. On noting radiographic findings, cardiomegaly (32.5%) was the most common finding. Electrocardiography testing obtained ST segment elevation among 44.8% patients and T wave inversion in 7.3% of the sample. Cardiovascular magnetic resonance imaging yielded 83.3% patients with myocardial edema, with late gadolinium enhancement in 63.9% patients. In hospital management consisted of azithromycin (25.5%), methylprednisolone/steroids (8.5%), and other standard care treatments for COVID-19. The most common in-hospital complication included acute respiratory distress syndrome (66.4%) and cardiogenic shock (14%). On last follow up, 64.7% of the patients survived, whereas 31.8% patients did not survive, and 3.5% were in the critical care unit. Conclusion: It is essential to demarcate COVID-19 infection and myocarditis presentations due to the heightened risk of death among patients contracting both myocardial inflammation and ARDS. With a multitude of diagnostic and treatment options available for COVID-19 and myocarditis, patients that are under high risk of suspicion for COVID-19 induced myocarditis must be appropriately diagnosed and treated to curb co-infections. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2150-1327 21501327 |
| Relation: | https://doaj.org/toc/2150-1327 |
| DOI: | 10.1177/21501327211056800 |
| URL الوصول: | https://doaj.org/article/56cbe7c3c8bd4b2a87eac2d5878feb01 |
| رقم الانضمام: | edsdoj.56cbe7c3c8bd4b2a87eac2d5878feb01 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 21501327 |
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| DOI: | 10.1177/21501327211056800 |