التفاصيل البيبلوغرافية
| العنوان: |
The immune checkpoint VISTA is associated with prognosis in patients with malignant uveal melanoma |
| المؤلفون: |
Nour el Imane Issam Salah, Farida Marnissi, Abdelhakim Lakhdar, Mehdi Karkouri, Mohamed ElBelhadji, Abdallah Badou |
| المصدر: |
Frontiers in Immunology, Vol 14 (2023) |
| بيانات النشر: |
Frontiers Media S.A., 2023. |
| سنة النشر: |
2023 |
| المجموعة: |
LCC:Immunologic diseases. Allergy |
| مصطلحات موضوعية: |
VISTA, PD1, CTLA-4, uveal melanoma, cancer immunotherapy, immune checkpoint inhibitor, Immunologic diseases. Allergy, RC581-607 |
| الوصف: |
IntroductionUveal melanoma (UM) is a rare yet deadly tumor. It is known for its high metastatic potential, which makes it one of the most aggressive and lethal cancers. Recently, immune checkpoints such as Programmed cell Death protein-1 (PD1) and Cytotoxic T-Lymphocyte-Associated significantly increasing patient survival in multiple human cancers, especially cutaneous melanoma. However, patients with UMs were excluded from these studies because of their molecular characteristics, which tend to be widely different from those of cutaneous melanoma. This study aimed to analyze the expression of V domain Ig Suppressor T-cell Activation (VISTA), a novel immune checkpoint, to evaluate its prognosis significance and its correlation with PD1 and CTLA-4.MethodsEvaluation of VISTA, CTLA-4, and PD1 expression was performed through TCGA database analysis and immunohistochemistry using two independent cohorts with primary malignant UM.Results and discussionOur results showed that VISTA expression was associated with tumor aggressiveness, T cell exhaustion, and the shortest median overall survival among patients. Surprisingly, PD1 protein expression was negative in all patients, whereas CTLA-4 expression was high in patients with advanced stages. Our findings suggest that VISTA may be a prognostic marker and an attractive treatment strategy for immunotherapy in patients with UM. Exploring its expression profile may predict response to immunotherapy and may lead to the improvement of precision therapy in malignant uveal melanoma patients. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1664-3224 |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fimmu.2023.1225140/full; https://doaj.org/toc/1664-3224 |
| DOI: |
10.3389/fimmu.2023.1225140 |
| URL الوصول: |
https://doaj.org/article/5639db9a3fde4c2d8c6a2cc8797e2369 |
| رقم الانضمام: |
edsdoj.5639db9a3fde4c2d8c6a2cc8797e2369 |
| قاعدة البيانات: |
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