Academic Journal
Transcriptional events during the recovery from MRSA lung infection: a mouse pneumonia model.
| العنوان: | Transcriptional events during the recovery from MRSA lung infection: a mouse pneumonia model. |
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| المؤلفون: | Jiwang Chen, Gang Feng, Qiang Guo, Juliane B Wardenburg, Simon Lin, Ichiro Inoshima, Ryan Deaton, Jason X J Yuan, Joe G N Garcia, Roberto F Machado, Michael Otto, Richard G Wunderink |
| المصدر: | PLoS ONE, Vol 8, Iss 8, p e70176 (2013) |
| بيانات النشر: | Public Library of Science (PLoS), 2013. |
| سنة النشر: | 2013 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Medicine, Science |
| الوصف: | Community associated methicillin-resistant Staphylococcus aureus (CA-MRSA) is an emerging threat to human health throughout the world. Rodent MRSA pneumonia models mainly focus on the early innate immune responses to MRSA lung infection. However, the molecular pattern and mechanisms of recovery from MRSA lung infection are largely unknown. In this study, a sublethal mouse MRSA pneumonia model was employed to investigate late events during the recovery from MRSA lung infection. We compared lung bacterial clearance, bronchoalveolar lavage fluid (BALF) characterization, lung histology, lung cell proliferation, lung vascular permeability and lung gene expression profiling between days 1 and 3 post MRSA lung infection. Compared to day 1 post infection, bacterial colony counts, BALF total cell number and BALF protein concentration significantly decreased at day 3 post infection. Lung cDNA microarray analysis identified 47 significantly up-regulated and 35 down-regulated genes (p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1932-6203 |
| Relation: | http://europepmc.org/articles/PMC3731344?pdf=render; https://doaj.org/toc/1932-6203 |
| DOI: | 10.1371/journal.pone.0070176 |
| URL الوصول: | https://doaj.org/article/55b5247d5be348b9ba1e5e28b657b9ef |
| رقم الانضمام: | edsdoj.55b5247d5be348b9ba1e5e28b657b9ef |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 19326203 |
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| DOI: | 10.1371/journal.pone.0070176 |