Academic Journal

Toxin genotypes, antibiotic resistance and their correlations in Clostridioides difficile isolated from hospitals in Xi’an, China

التفاصيل البيبلوغرافية
العنوان: Toxin genotypes, antibiotic resistance and their correlations in Clostridioides difficile isolated from hospitals in Xi’an, China
المؤلفون: Sukai Zhang, Chen Ma, Haiyue Zhang, Congcong Zhao, Ruibing Guo, Jiahao Liu, Jing Wang, Jing Yuan, Kai Jia, Airong Wu, Yanjiong Chen, Jin’e Lei
المصدر: BMC Microbiology, Vol 24, Iss 1, Pp 1-10 (2024)
بيانات النشر: BMC, 2024.
سنة النشر: 2024
المجموعة: LCC:Microbiology
مصطلحات موضوعية: Clostridioides difficile, Toxin genes, Toxin gene expression, Antibiotic resistance, Microbiology, QR1-502
الوصف: Abstract Background Clostridioides difficile is the main pathogen of antimicrobial-associated diarrhoea and health care facility-associated infectious diarrhoea. This study aimed to investigate the prevalence, toxin genotypes, and antibiotic resistance of C. difficile among hospitalized patients in Xi’an, China. Results We isolated and cultured 156 strains of C. difficile, representing 12.67% of the 1231 inpatient stool samples collected. Among the isolates, tcdA + B + strains were predominant, accounting for 78.2% (122/156), followed by 27 tcdA-B + strains (27/156, 17.3%) and 6 binary toxin gene-positive strains. The positive rates of three regulatory genes, tcdC, tcdR, and tcdE, were 89.1% (139/156), 96.8% (151/156), and 100%, respectively. All isolates were sensitive to metronidazole, and the resistance rates to clindamycin and cephalosporins were also high. Six strains were found to be resistant to vancomycin. Conclusion Currently, the prevalence rate of C. difficile infection (CDI) in Xi’an is 12.67% (156/1231), with the major toxin genotype of the isolates being tcdA + tcdB + cdtA-/B-. Metronidazole and vancomycin were still effective drugs for the treatment of CDI, but we should pay attention to antibiotic management and epidemiological surveillance of CDI.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1471-2180
Relation: https://doaj.org/toc/1471-2180
DOI: 10.1186/s12866-024-03327-z
URL الوصول: https://doaj.org/article/5507ca0a1c974ea8a3e45e7e5c41f51c
رقم الانضمام: edsdoj.5507ca0a1c974ea8a3e45e7e5c41f51c
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:14712180
DOI:10.1186/s12866-024-03327-z