التفاصيل البيبلوغرافية
| العنوان: |
Efficacy of dupilumab for airway hypersecretion and airway wall thickening in patients with moderate-to-severe asthma: A prospective, observational study |
| المؤلفون: |
Tomoko Tajiri, Motohiko Suzuki, Hirono Nishiyama, Yoshiyuki Ozawa, Ryota Kurokawa, Norihisa Takeda, Keima Ito, Kensuke Fukumitsu, Yoshihiro Kanemitsu, Yuta Mori, Satoshi Fukuda, Takehiro Uemura, Hirotsugu Ohkubo, Masaya Takemura, Ken Maeno, Yutaka Ito, Tetsuya Oguri, Kenji Izuhara, Akio Niimi |
| المصدر: |
Allergology International, Vol 73, Iss 3, Pp 406-415 (2024) |
| بيانات النشر: |
Elsevier, 2024. |
| سنة النشر: |
2024 |
| المجموعة: |
LCC:Immunologic diseases. Allergy |
| مصطلحات موضوعية: |
Asthma, Airway hyperresponsiveness, Airway hypersecretion, Airway remodeling, Dupilumab, Immunologic diseases. Allergy, RC581-607 |
| الوصف: |
Background: Dupilumab has clinical effects in patients with moderate-to-severe asthma. When considering interleukin (IL)-4 and IL-13 signaling, effects of dupilumab on airway mucus hypersecretion and airway remodeling are expected, but they have been reported in only a few short-term studies. Its efficacy for airway hyperresponsiveness (AHR) remains unknown. We comprehensively assessed the efficacy of dupilumab, especially for subjective and objective measures of airway mucus hypersecretion and airway dimensions in moderate-to-severe asthmatic patients. Methods: In 28 adult patients with moderate-to-severe uncontrolled asthma, the comprehensive efficacy of 48-week dupilumab treatment, including the Cough and Sputum Assessment Questionnaire (CASA-Q), radiological mucus scores and airway dimensions on computed tomography (CT), was assessed prospectively. Treatment responsiveness to dupilumab was analyzed. Results: With 48-week dupilumab treatment, all four cough and sputum domain scores of CASA-Q improved significantly. Radiological mucus scores and airway wall thickening on CT were significantly decreased. The decreases in mucus scores were significantly associated with improvements in Asthma Control Questionnaire scores, Asthma Quality of Life Questionnaire (AQLQ) overall scores, airway obstruction, and airway type 2 inflammation. When defined by > 0.5 improvement in AQLQ overall scores, 18 patients (64%) were identified as responders. Conclusions: Dupilumab reversed subjective and objective measures of airway mucus hypersecretion and some aspects of airway remodeling in patients with moderate-to-severe uncontrolled asthma. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1323-8930 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S1323893024000169; https://doaj.org/toc/1323-8930 |
| DOI: |
10.1016/j.alit.2024.02.002 |
| URL الوصول: |
https://doaj.org/article/54aaf13e615b4d6ba77f3fe4a3a4bbae |
| رقم الانضمام: |
edsdoj.54aaf13e615b4d6ba77f3fe4a3a4bbae |
| قاعدة البيانات: |
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