التفاصيل البيبلوغرافية
| العنوان: |
Dialysis Preparation of Smart Redox and Acidity Dual Responsive Tea Polyphenol Functionalized Calcium Phosphate Nanospheres as Anticancer Drug Carriers |
| المؤلفون: |
Xiuli Ren, Peng Zhang, Zhenhua Chen |
| المصدر: |
Molecules, Vol 25, Iss 5, p 1221 (2020) |
| بيانات النشر: |
MDPI AG, 2020. |
| سنة النشر: |
2020 |
| المجموعة: |
LCC:Organic chemistry |
| مصطلحات موضوعية: |
calcium phosphate, nanospheres, drug delivery, ph-responsive, doxorubicin, Organic chemistry, QD241-441 |
| الوصف: |
Large-scale preparation of biocompatible drug delivery systems with targeted recognition and controlled release properties has always been attractive. However, this strategy has been constrained by a lot of design challenges, such as complicated steps and premature drug release. Herein, in this paper, we address these problems by a facile in situ mineralization method, which synthesizes biodegradable tea polyphenol coated monodisperse calcium phosphate nanospheres using for targeted and controlled delivery of doxorubicin. Dialysis diffusion method was used to control ion release to form mineralized nanospheres. The polyphenol coatings and calcium phosphate used in this work could be biodegraded by intracellular glutathione and acidic microenvironment, respectively, resulting the release of encapsulated drug. According to confocal fluorescence microscopy, and cytotoxicity experiments, the prepared tea polyphenol functionalized, doxorubicin loaded calcium phosphate nanospheres were confirmed to have highly efficient internalization and obvious cell killing effect on target tumor cells, but not normal cells. Our results suggest that these tea polyphenols functionalized calcium phosphate nanospheres are promising vehicles for controlled release of an anticancer drug in cancer therapy. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1420-3049 |
| Relation: |
https://www.mdpi.com/1420-3049/25/5/1221; https://doaj.org/toc/1420-3049 |
| DOI: |
10.3390/molecules25051221 |
| URL الوصول: |
https://doaj.org/article/545a3ac90cfc4aae858c56d55c4ee40c |
| رقم الانضمام: |
edsdoj.545a3ac90cfc4aae858c56d55c4ee40c |
| قاعدة البيانات: |
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