Academic Journal
The p53-Driven Anticancer Effect of Ribes fasciculatum Extract on AGS Gastric Cancer Cells
| العنوان: | The p53-Driven Anticancer Effect of Ribes fasciculatum Extract on AGS Gastric Cancer Cells |
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| المؤلفون: | Myeong-Jin Kim, Hye-Won Kawk, Sang-Hyeon Kim, Hyo-Jae Lee, Ji-Won Seo, Chang-Yeol Lee, Young-Min Kim |
| المصدر: | Life, Vol 12, Iss 2, p 303 (2022) |
| بيانات النشر: | MDPI AG, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Science |
| مصطلحات موضوعية: | Ribes fasciculatum, AGS, metastasis, anoikis resistance, apoptosis, EGFR, Science |
| الوصف: | Cancer metastasis is directly related to the survival rate of cancer patients. Although cancer metastasis proceeds by the movement of cancer cells, it is fundamentally caused by its resistance to anoikis, a mechanism of apoptosis caused by the loss of adhesion of cancer cells. Therefore, it was found that inhibiting cancer migration and reducing anoikis resistance are important for cancer suppression, and natural compounds can effectively control it. Among them, Ribes fasciculatum, which has been used as a medicinal plant, was confirmed to have anticancer potential, and experiments were conducted to prove various anticancer effects by extracting Ribes fasciculatum (RFE). Through various experiments, it was observed that RFE induces apoptosis of AGS gastric cancer cells, arrests the cell cycle, induces oxidative stress, and reduces mobility. It was also demonstrated that anoikis resistance was attenuated through the downregulation of proteins, such as epidermal growth factor receptor (EGFR). Moreover, the anticancer effect of RFE depends upon the increase in p53 expression, suggesting that RFE is suitable for the development of p53-targeted anticancer materials. Moreover, through xenotransplantation, it was found that the anticancer effect of RFE confirmed in vitro was continued in vivo. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 12020303 2075-1729 |
| Relation: | https://www.mdpi.com/2075-1729/12/2/303; https://doaj.org/toc/2075-1729 |
| DOI: | 10.3390/life12020303 |
| URL الوصول: | https://doaj.org/article/e54594343f2e4eddb858b0a212c7f19e |
| رقم الانضمام: | edsdoj.54594343f2e4eddb858b0a212c7f19e |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 12020303 20751729 |
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| DOI: | 10.3390/life12020303 |