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Emerging roles of TFE3 in metabolic regulation

التفاصيل البيبلوغرافية
العنوان: Emerging roles of TFE3 in metabolic regulation
المؤلفون: Xingyu Li, Yongming Chen, Siqiao Gong, Huixia Chen, Huafeng Liu, Xiaoyu Li, Junfeng Hao
المصدر: Cell Death Discovery, Vol 9, Iss 1, Pp 1-9 (2023)
بيانات النشر: Nature Publishing Group, 2023.
سنة النشر: 2023
المجموعة: LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
LCC:Cytology
مصطلحات موضوعية: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Cytology, QH573-671
الوصف: Abstract TFE3 is a member of the MiT family of the bHLH-leucine zipper transcription factor. We previously focused on the role of TFE3 in autophagy and cancer. Recently, an increasing number of studies have revealed that TFE3 plays an important role in metabolic regulation. TFE3 participates in the metabolism of energy in the body by regulating pathways such as glucose and lipid metabolism, mitochondrial metabolism, and autophagy. This review summarizes and discusses the specific regulatory mechanisms of TFE3 in metabolism. We determined both the direct regulation of TFE3 on metabolically active cells, such as hepatocytes and skeletal muscle cells, and the indirect regulation of TFE3 through mitochondrial quality control and the autophagy–lysosome pathway. The role of TFE3 in tumor cell metabolism is also summarized in this review. Understanding the diverse roles of TFE3 in metabolic processes can provide new avenues for the treatment of some metabolism-related disorders.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2058-7716
Relation: https://doaj.org/toc/2058-7716
DOI: 10.1038/s41420-023-01395-0
URL الوصول: https://doaj.org/article/accdceaacd544d35a6fbb75ae800dca7
رقم الانضمام: edsdoj.544d35a6fbb75ae800dca7
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20587716
DOI:10.1038/s41420-023-01395-0