التفاصيل البيبلوغرافية
| العنوان: |
Functional activity, functional connectivity and complex network biomarkers of progressive hyposmia Parkinson’s disease with no cognitive impairment: evidences from resting-state fMRI study |
| المؤلفون: |
Lei Geng, Wenfei Cao, Juan Zuo, Hongjie Yan, Jinxin Wan, Yi Sun, Nizhuan Wang |
| المصدر: |
Frontiers in Aging Neuroscience, Vol 16 (2024) |
| بيانات النشر: |
Frontiers Media S.A., 2024. |
| سنة النشر: |
2024 |
| المجموعة: |
LCC:Neurosciences. Biological psychiatry. Neuropsychiatry |
| مصطلحات موضوعية: |
Parkinson’s disease, hyposmia, amplitude of low-frequency fluctuation, regional homogeneity, functional connectivity, brain functional network, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571 |
| الوصف: |
BackgroundOlfactory dysfunction stands as one of the most prevalent non-motor symptoms in the initial stage of Parkinson’s disease (PD). Nevertheless, the intricate mechanisms underlying olfactory deficits in Parkinson’s disease still remain elusive.MethodsThis study collected rs-fMRI data from 30 PD patients [15 with severe hyposmia (PD-SH) and 15 with no/mild hyposmia (PD-N/MH)] and 15 healthy controls (HC). To investigate functional segregation, the amplitude of low-frequency fluctuation (ALFF) and regional homogeneity (ReHo) were utilized. Functional connectivity (FC) analysis was performed to explore the functional integration across diverse brain regions. Additionally, the graph theory-based network analysis was employed to assess functional networks in PD patients. Furthermore, Pearson correlation analysis was conducted to delve deeper into the relationship between the severity of olfactory dysfunction and various functional metrics.ResultsWe discovered pronounced variations in ALFF, ReHo, FC, and topological brain network attributes across the three groups, with several of these disparities exhibiting a correlation with olfactory scores.ConclusionUsing fMRI, our study analyzed brain function in PD-SH, PD-N/MH, and HC groups, revealing impaired segregation and integration in PD-SH and PD-N/MH. We hypothesize that changes in temporal, frontal, occipital, and cerebellar activities, along with aberrant cerebellum-insula connectivity and node degree and betweenness disparities, may be linked to olfactory dysfunction in PD patients. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1663-4365 |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fnagi.2024.1455020/full; https://doaj.org/toc/1663-4365 |
| DOI: |
10.3389/fnagi.2024.1455020 |
| URL الوصول: |
https://doaj.org/article/54372a0031624a00be2a8a8a4478ac6f |
| رقم الانضمام: |
edsdoj.54372a0031624a00be2a8a8a4478ac6f |
| قاعدة البيانات: |
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