التفاصيل البيبلوغرافية
| العنوان: |
Applicability of the Sarculator and MSKCC nomograms to retroperitoneal sarcoma prognostication in an Asian tertiary center |
| المؤلفون: |
Ru Xin Wong, Yen Sin Koh, Faith Ong, M. Farid, Timothy Kwang Yong Tay, Melissa Teo |
| المصدر: |
Asian Journal of Surgery, Vol 43, Iss 11, Pp 1078-1085 (2020) |
| بيانات النشر: |
Elsevier, 2020. |
| سنة النشر: |
2020 |
| المجموعة: |
LCC:Surgery |
| مصطلحات موضوعية: |
Nomograms, Neoplasm grading, Peritoneum, Sarcoma, Surgery, RD1-811 |
| الوصف: |
Aim: To study the applicability of 2 common nomograms in retroperitoneal sarcoma patients treated in an Asian tertiary hospital, and to study relapse patterns. Methods: Patients from 1st January 2000 to 31st December 2017 were retrospectively analysed. R2 resection from an external institution were ineligible. Harrel's C concordance index and calibration plots were used to assess nomograms' accuracy. Results: 109 patients were eligible, with a median age of 56, median tumour size of 16 cm and median follow up of 44.1 months. Most common subtypes were DDLPS (46.8%), LMS (19.3%) and WDLPS (13.8%). Overall, 81.1% had passed away from sarcoma. Recurrence patterns differed with subtypes; 6.7% of WDLPS and 66.7% of LMS had distant relapses. WDLPS patients had a median sarcoma specific survival of 139 months (122-NA), while the rest had a median SSS of 72.3 months (59.7-NA). The 5-years and 7-year OS were 63.0% (95% CI: 53.6%–74.0%) and 51.6% (41.1%–64.8%) respectively. The 5-years and 7-year DFS were 22.4% (15.5%–32.3%) and 17.5% (11%–27.8%) respectively. The 4-years, 8-years and 12-year SSS were 71.3% (62.7%–81.0%), 51.8% (40.8%–65.8%) and 32.2% (19.7%–52.6%) respectively. The concordance indices for 7-year DFS and OS (Sarculator) were 0.63 and 0.73. The concordance indices for 4-, 8- and 12-year SSS (MSKCC) were 0.64, 0.72 and 0.72. Conclusion: Both nomograms were effective in our cohort. Both nomograms can be further improved by specifying the type of relapse and including a longer-term endpoint for the Sarculator. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1015-9584 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S1015958420300105; https://doaj.org/toc/1015-9584 |
| DOI: |
10.1016/j.asjsur.2020.01.005 |
| URL الوصول: |
https://doaj.org/article/54243c76c07949d797ab287f2d875238 |
| رقم الانضمام: |
edsdoj.54243c76c07949d797ab287f2d875238 |
| قاعدة البيانات: |
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