Academic Journal
不同血糖状态和年龄变化的成年人动脉硬化风险的性别差异
| العنوان: | 不同血糖状态和年龄变化的成年人动脉硬化风险的性别差异 |
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| المؤلفون: | Xiaoyun Zhang, Qianqian Yang, Ruizhi Zheng, Zhiyun Zhao, Mian Li, Tiange Wang, Min Xu, Jieli Lu, Shuangyuan Wang, Hong Lin, Weiqing Wang, Guang Ning, Yufang Bi, Yu Xu, Yuhong Chen |
| المصدر: | Journal of Diabetes, Vol 15, Iss 2, Pp 121-132 (2023) |
| بيانات النشر: | Wiley, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Diseases of the endocrine glands. Clinical endocrinology |
| مصطلحات موضوعية: | 性别差异, 动脉硬化指数, 血糖状态, 年龄, Diseases of the endocrine glands. Clinical endocrinology, RC648-665 |
| الوصف: | Abstract Background Studies indicate lower, comparable, and higher cardiovascular risks in women vs men in normal glucose regulation (NGR), prediabetes, and diabetes, respectively. However, this sex difference is uncertain and aging might play a part. We aimed to estimate sex differences in arterial stiffness in NGR, prediabetes, or diabetes and the potential modifications by age. Methods We used baseline data of 9618 participants aged ≥40 years in a large community‐based cohort study in Shanghai. Glycemic status was determined by history of diabetes, fasting and 2‐h post‐load glucose levels, and hemoglobin A1c levels. Arterial stiffness was examined by brachial‐ankle pulse wave velocity (ba‐PWV). Multivariable linear regression analysis was conducted to examine the associations between sex and ba‐PWV levels in glycemic and age categories. Results Before adjustment for age, women had lower, comparable, and higher ba‐PWV vs men in the NGR, prediabetes, and diabetes groups, respectively. In participants aged 40–59 years, women were associated with lower ba‐PWV levels in generally all glycemic strata after adjustment for age and other confounders. In participants aged ≥60 years, women were associated with significantly higher ba‐PWV levels (β coefficient = 71.5; 95% confidence interval = 23.4, 119.7) and the sex difference was attenuated in the groups of prediabetes and diabetes with a borderline significant interaction between sex and glycemic status (p for interaction = .068). Conclusions The sex difference in cardiovascular risks in adults with NGR, prediabetes, or diabetes was dependent on age. Our findings provide new evidence for prioritizing preventive treatment against atherosclerosis in men vs women with different glycemic status. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1753-0407 1753-0393 |
| Relation: | https://doaj.org/toc/1753-0393; https://doaj.org/toc/1753-0407 |
| DOI: | 10.1111/1753-0407.13353 |
| URL الوصول: | https://doaj.org/article/54022c14c30c456a9fab392a96351778 |
| رقم الانضمام: | edsdoj.54022c14c30c456a9fab392a96351778 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 17530407 17530393 |
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| DOI: | 10.1111/1753-0407.13353 |