Academic Journal
Dosimetry during adjuvant 131I therapy in patients with differentiated thyroid cancer-clinical implications
| العنوان: | Dosimetry during adjuvant 131I therapy in patients with differentiated thyroid cancer-clinical implications |
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| المؤلفون: | Piotr Szumowski, Saeid Abdelrazek, Dorota Iwanicka, Małgorzata Mojsak, Monika Sykała, Łukasz Żukowski, Katarzyna Siewko, Agnieszka Adamska, Katarzyna Maliszewska, Anna Popławska-Kita, Małgorzata Szelachowska, Adam Krętowski, Janusz Myśliwiec |
| المصدر: | Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021) |
| بيانات النشر: | Nature Portfolio, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Medicine, Science |
| الوصف: | Abstract The activity of radioiodine (131I) used in adjuvant therapy for thyroid cancer ranges between 30 mCi (1.1 GBq) and 150 mCi (5.5 GBq). Dosimetry based on Marinelli's formula, taking into consideration the absorbed dose in the postoperative tumour bed (D) should systematise the determination of 131I activity. Retrospective analysis of 57 patients with differentiated thyroid cancer (DTC) after thyreidectomy and adjuvant 131I therapy with the fixed activity of 3.7 GBq. In order to calculate D from Marinelli's formula, the authors took into account, among other things, repeated dosimetry measurements (after 6, 24, and 72 h) made during scintigraphy and after administration of the therapeutic activity or radioiodine. In 75% of the patients, the values of D were > 300 Gy (i.e. above the value recommended by current guidelines). In just 16% of the patients, the obtained values fell between 250 and 300 Gy, whereas in 9% of the patients, the value of D was |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2045-2322 |
| Relation: | https://doaj.org/toc/2045-2322 |
| DOI: | 10.1038/s41598-021-93431-1 |
| URL الوصول: | https://doaj.org/article/53bc6359f80e42cdba7bf852ce594c13 |
| رقم الانضمام: | edsdoj.53bc6359f80e42cdba7bf852ce594c13 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20452322 |
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| DOI: | 10.1038/s41598-021-93431-1 |