التفاصيل البيبلوغرافية
| العنوان: |
A novel molecular pathway of lipid accumulation in human hepatocytes caused by PFOA and PFOS |
| المؤلفون: |
Xiao Gou, Mingming Tian, Lu Yan, Pu Xia, Huimin Ji, Haoyue Tan, Wei Shi, Hongxia Yu, Xiaowei Zhang |
| المصدر: |
Environment International, Vol 191, Iss , Pp 108962- (2024) |
| بيانات النشر: |
Elsevier, 2024. |
| سنة النشر: |
2024 |
| المجموعة: |
LCC:Environmental sciences |
| مصطلحات موضوعية: |
PFOA and PFOS, Lipid accumulation, Lipid metabolism disorder, NAFLD, Adverse outcome pathway, Human-relevantexposure, Environmental sciences, GE1-350 |
| الوصف: |
Exposed to ubiquitously perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) has been associated with non-alcoholic fatty liver disease (NAFLD), yet the underlying molecular mechanism remains elusive. The extrapolation of empirical studies correlating per- and polyfluoroalkyl substance (PFAS) exposure with NAFLD occurrence to real-life exposure was hindered by the limited availability of mechanistic data at environmentally relevant concentrations. Herein, a novel pathway mediating hepatocyte lipid accumulation by PFOA and PFOS at human-relevant dose ( |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
0160-4120 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S0160412024005488; https://doaj.org/toc/0160-4120 |
| DOI: |
10.1016/j.envint.2024.108962 |
| URL الوصول: |
https://doaj.org/article/537f0b403e2049189bff8eb0762da428 |
| رقم الانضمام: |
edsdoj.537f0b403e2049189bff8eb0762da428 |
| قاعدة البيانات: |
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