التفاصيل البيبلوغرافية
| العنوان: |
Metabolite Transporters as Regulators of Immunity |
| المؤلفون: |
Hauke J. Weiss, Stefano Angiari |
| المصدر: |
Metabolites, Vol 10, Iss 10, p 418 (2020) |
| بيانات النشر: |
MDPI AG, 2020. |
| سنة النشر: |
2020 |
| المجموعة: |
LCC:Microbiology |
| مصطلحات موضوعية: |
cell metabolism, immunity, metabolite transporter, solute carrier, T cells, macrophages, Microbiology, QR1-502 |
| الوصف: |
In the past decade, the rise of immunometabolism has fundamentally reshaped the face of immunology. As the functions and properties of many (immuno)metabolites have now been well described, their exchange among cells and their environment have only recently sparked the interest of immunologists. While many metabolites bind specific receptors to induce signaling cascades, some are actively exchanged between cells to communicate, or induce metabolic reprograming. In this review, we give an overview about how active metabolite transport impacts immune cell function and shapes immunological responses. We present some examples of how specific transporters feed into metabolic pathways and initiate intracellular signaling events in immune cells. In particular, we focus on the role of metabolite transporters in the activation and effector functions of T cells and macrophages, as prototype adaptive and innate immune cell populations. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2218-1989 |
| Relation: |
https://www.mdpi.com/2218-1989/10/10/418; https://doaj.org/toc/2218-1989 |
| DOI: |
10.3390/metabo10100418 |
| URL الوصول: |
https://doaj.org/article/52ed439d15024bc8afbf4ddbb4ae1d8e |
| رقم الانضمام: |
edsdoj.52ed439d15024bc8afbf4ddbb4ae1d8e |
| قاعدة البيانات: |
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