Academic Journal
In vitro assessment of selected Korean plants for antioxidant and antiacetylcholinesterase activities
| العنوان: | In vitro assessment of selected Korean plants for antioxidant and antiacetylcholinesterase activities |
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| المؤلفون: | Seulah Lee, Dahae Lee, Jiwon Baek, Eun Bee Jung, Ji Yun Baek, Il Kyun Lee, Tae Su Jang, Ki Sung Kang, Ki Hyun Kim |
| المصدر: | Pharmaceutical Biology, Vol 55, Iss 1, Pp 2205-2210 (2017) |
| بيانات النشر: | Taylor & Francis Group, 2017. |
| سنة النشر: | 2017 |
| المجموعة: | LCC:Therapeutics. Pharmacology |
| مصطلحات موضوعية: | prunella vulgaris var. lilacina, oenothera biennis, pharbitis nil, Therapeutics. Pharmacology, RM1-950 |
| الوصف: | Context: Antiacetylcholinesterase (AChE) drugs have been a main therapeutic treatment for Alzheimer’s disease because increased AChE levels play a key role in reducing neurotransmission. Objectives: Extracts from 35 Korean plants were selected and screened for antioxidant and anti-cholinesterase activity to explore new sources derived from Korean natural resources that could be used as AD therapeutic agents. Materials and methods: The antioxidant effect of extracts from 35 selected Korean plants was determined using two most common free radical scavenging assays using 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2′-azino-bis-3-ethylbenzthiazoline-6-sulphonic acid (ABTS). Additionally, the effect of extracts, identified as antioxidants, on acetylcholinesterase inhibition was assessed by an acetylcholinesterase assay kit. Results: Out of 36 extracts of 35 plants tested, Oenothera biennis L. (9.09 μg/mL), Saururus chinensis (Lour.) Baill. (9.52 μg/mL) and Betula platyphylla var. japonica (9.85 μg/mL) showed strong DPPH scavenging activity. Twelve other extracts also exerted moderate free radical scavenging activities with IC50 values ranging from 10 to 50 μg/mL. Antioxidant capacity detected by ABTS assay was only significant in O. biennis (23.40 μg/mL), while the other extracts were weak or unable to reduce the production of ABTS. Based on the antioxidant activities of these plant extracts, 19 extracts with IC50 values less than 100 μg/mL in DPPH assay were selected for further AChE inhibition assay. Among the extracts tested, the IC50 value for Prunella vulgaris var. lilacina NAKAI (18.83 μg/mL) in AChE inhibitory activity was the lowest, followed by O. biennis (20.09 μg/mL) and Pharbitis nil Chosy (22.79 μg/mL). Conclusions: Considering complex multifactorial etiology of AD, the extracts of P. vulgaris var. lilacina (aerial part), O. biennis (seed) and P. nil (seed) may be safe and ideal candidates for future AD modifying therapies. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1388-0209 1744-5116 13880209 |
| Relation: | https://doaj.org/toc/1388-0209; https://doaj.org/toc/1744-5116 |
| DOI: | 10.1080/13880209.2017.1397179 |
| URL الوصول: | https://doaj.org/article/529a28edfa6f44d888c49c956ea7456b |
| رقم الانضمام: | edsdoj.529a28edfa6f44d888c49c956ea7456b |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 13880209 17445116 |
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| DOI: | 10.1080/13880209.2017.1397179 |