التفاصيل البيبلوغرافية
| العنوان: |
Two parallel medial prefrontal cortex-amygdala pathways mediate memory deficits via glutamatergic projection in surgery mice |
| المؤلفون: |
Xiao-Yu Sun, Le Liu, Yu-Tong Song, Tong Wu, Teng Zheng, Jing-Ru Hao, Jun-Li Cao, Can Gao |
| المصدر: |
Cell Reports, Vol 42, Iss 7, Pp 112719- (2023) |
| بيانات النشر: |
Elsevier, 2023. |
| سنة النشر: |
2023 |
| المجموعة: |
LCC:Biology (General) |
| مصطلحات موضوعية: |
CP: Neuroscience, Biology (General), QH301-705.5 |
| الوصف: |
Summary: The neural circuit mechanisms underlying postoperative cognitive dysfunction (POCD) remain elusive. We hypothesized that projections from the medial prefrontal cortex (mPFC) to the amygdala are involved in POCD. A mouse model of POCD in which isoflurane (1.5%) combined with laparotomy was used. Virally assisted tracing techniques were used to label the relevant pathways. Fear conditioning, immunofluorescence, whole-cell patch-clamp recordings, and chemogenetic and optogenetic techniques were applied to investigate the role of mPFC-amygdala projections in POCD. We find that surgery impairs memory consolidation but not retrieval of consolidated memories. In POCD mice, the glutamatergic pathway from the prelimbic cortex to the basolateral amygdala (PL-BLA) shows reduced activity, whereas the glutamatergic pathway from the infralimbic cortex to the basomedial amygdala (IL-BMA) shows enhanced activity. Our study indicates that the hypoactivity in the PL-BLA pathway interrupts memory consolidation, whereas the hyperactivity in the IL-BMA promotes memory extinction, in POCD mice. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2211-1247 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S2211124723007301; https://doaj.org/toc/2211-1247 |
| DOI: |
10.1016/j.celrep.2023.112719 |
| URL الوصول: |
https://doaj.org/article/51d728f16f4f48d795b1c19a6cecd813 |
| رقم الانضمام: |
edsdoj.51d728f16f4f48d795b1c19a6cecd813 |
| قاعدة البيانات: |
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