التفاصيل البيبلوغرافية
| العنوان: |
Acute HIV infection presenting as hemophagocytic syndrome with an unusual serological and virological response to ART |
| المؤلفون: |
Rita Veiga Ferraz, Ana Cláudia Carvalho, Fernando Araújo, Carmo Koch, Cândida Abreu, António Sarmento |
| المصدر: |
BMC Infectious Diseases, Vol 16, Iss 1, Pp 1-5 (2016) |
| بيانات النشر: |
BMC, 2016. |
| سنة النشر: |
2016 |
| المجموعة: |
LCC:Infectious and parasitic diseases |
| مصطلحات موضوعية: |
HIV, Acute infection, Haemophagocytic syndrome, Infectious and parasitic diseases, RC109-216 |
| الوصف: |
Abstract Background HIV clinical presentation in the acute stage is variable and some of its virological and immunological aspects are not completely understood. Most cases of HIV- associated reactive hemophagocytic syndrome have been reported in patients with advanced stages of HIV and to our knowledge, there are only 8 cases in the English literature presenting during acute HIV infection, most in East Asia, being this the first case in a European patient. Case presentation We report a case of a European Caucasian 27- year old woman with a primary HIV- infection presenting with extremely low CD4+ T cell count who developed a haemophagocytic syndrome after starting ART and in whom we documented a very unusual serological and virological response, characterized by an impaired HIV- antibody production and a 12 month time frame to reach an undetectable viral load, despite no evidence of resistance. Conclusions This case report apart from describing an unusual clinical presentation of an acute HIV infection as hemophagocytic syndrome provides useful information that might contribute for understanding some subtle issues in acute HIV infection, namely the dynamics of virological and immunological aspects after antiretroviral therapy initiation. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1471-2334 |
| Relation: |
http://link.springer.com/article/10.1186/s12879-016-1945-9; https://doaj.org/toc/1471-2334 |
| DOI: |
10.1186/s12879-016-1945-9 |
| URL الوصول: |
https://doaj.org/article/5155e5dc75ff47a9a070336af4662069 |
| رقم الانضمام: |
edsdoj.5155e5dc75ff47a9a070336af4662069 |
| قاعدة البيانات: |
Directory of Open Access Journals |
Full Text Finder