Academic Journal
Wound Healing after Acellular Dermal Substitute Positioning in Dermato-Oncological Surgery: A Prospective Comparative Study
| العنوان: | Wound Healing after Acellular Dermal Substitute Positioning in Dermato-Oncological Surgery: A Prospective Comparative Study |
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| المؤلفون: | Alessia Paganelli, Andrea Giovanni Naselli, Laura Bertoni, Elena Rossi, Paola Azzoni, Alessandra Pisciotta, Anna Maria Cesinaro, Luisa Benassi, Shaniko Kaleci, Federico Garbarino, Barbara Ferrari, Chiara Fiorentini, Camilla Reggiani, Cristina Magnoni |
| المصدر: | Life, Vol 13, Iss 2, p 463 (2023) |
| بيانات النشر: | MDPI AG, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Science |
| مصطلحات موضوعية: | dermal substitute, dermatologic surgery, skin cancer, wound healing, collagen, Science |
| الوصف: | Background: MatriDerm and Integra are both widely used collagenic acellular dermal matrices (ADMs) in the surgical setting, with similar characteristics in terms of healing time and clinical indication. The aim of the present study is to compare the two ADMs in terms of clinical and histological results in the setting of dermato-oncological surgery. Methods: Ten consecutive patients with medical indications to undergo surgical excision of skin cancers were treated with a 2-step procedure at our Dermatologic Surgery Unit. Immediately after tumor removal, both ADMs were positioned on the wound bed, one adjacent to the other. Closure through split-thickness skin grafting was performed after approximately 3 weeks. Conventional histology, immunostaining and ELISA assay were performed on cutaneous samples at different timepoints. Results: No significant differences were detected in terms of either final clinical outcomes or in extracellular matrix content of the neoformed dermis. However, Matriderm was observed to induce scar retraction more frequently. In contrast, Integra was shown to carry higher infectious risk and to be more slowly reabsorbed into the wound bed. Sometimes foreign body-like granulomatous reactions were also observed, especially in Integra samples. Conclusions: Even in the presence of subtle differences between the ADMs, comparable global outcomes were demonstrated after dermato-oncological surgery. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 13020463 2075-1729 |
| Relation: | https://www.mdpi.com/2075-1729/13/2/463; https://doaj.org/toc/2075-1729 |
| DOI: | 10.3390/life13020463 |
| URL الوصول: | https://doaj.org/article/50b888f55cb1456694140116fef3d10b |
| رقم الانضمام: | edsdoj.50b888f55cb1456694140116fef3d10b |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 13020463 20751729 |
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| DOI: | 10.3390/life13020463 |