التفاصيل البيبلوغرافية
| العنوان: |
Nrf2 Modulation in Breast Cancer |
| المؤلفون: |
Somayyeh Ghareghomi, Mehran Habibi-Rezaei, Marzia Arese, Luciano Saso, Ali Akbar Moosavi-Movahedi |
| المصدر: |
Biomedicines, Vol 10, Iss 10, p 2668 (2022) |
| بيانات النشر: |
MDPI AG, 2022. |
| سنة النشر: |
2022 |
| المجموعة: |
LCC:Biology (General) |
| مصطلحات موضوعية: |
oxidative stress, antioxidant pathway, Keap1-Nrf2, breast cancer, Nrf2 inhibitors, Biology (General), QH301-705.5 |
| الوصف: |
Reactive oxygen species (ROS) are identified to control the expression and activity of various essential signaling intermediates involved in cellular proliferation, apoptosis, and differentiation. Indeed, ROS represents a double-edged sword in supporting cell survival and death. Many common pathological processes, including various cancer types and neurodegenerative diseases, are inflammation and oxidative stress triggers, or even initiate them. Keap1-Nrf2 is a master antioxidant pathway in cytoprotective mechanisms through Nrf2 target gene expression. Activation of the Nfr2 pathway benefits cells in the early stages and reduces the level of ROS. In contrast, hyperactivation of Keap1-Nrf2 creates a context that supports the survival of both healthy and cancerous cells, defending them against oxidative stress, chemotherapeutic drugs, and radiotherapy. Considering the dual role of Nrf2 in suppressing or expanding cancer cells, determining its inhibitory/stimulatory position and targeting can represent an impressive role in cancer treatment. This review focused on Nrf2 modulators and their roles in sensitizing breast cancer cells to chemo/radiotherapy agents. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2227-9059 |
| Relation: |
https://www.mdpi.com/2227-9059/10/10/2668; https://doaj.org/toc/2227-9059 |
| DOI: |
10.3390/biomedicines10102668 |
| URL الوصول: |
https://doaj.org/article/5082c40d5d994c869c689e364a3593fd |
| رقم الانضمام: |
edsdoj.5082c40d5d994c869c689e364a3593fd |
| قاعدة البيانات: |
Directory of Open Access Journals |
Full Text Finder