التفاصيل البيبلوغرافية
| العنوان: |
Evaluating the diagnostic and prognostic utility of serial KL-6 measurements in connective tissue disease patients at risk for interstitial lung disease: correlations with pulmonary function tests and high-resolution computed tomography |
| المؤلفون: |
Jorge Álvarez Troncoso, Óscar Porto Fuentes, María Fernández Velilla, Luis Gómez Carrera, Clara Soto Abánades, Elena Martínez Robles, Raquel Sorriguieta Torre, Juan José Ríos Blanco |
| المصدر: |
BMC Pulmonary Medicine, Vol 24, Iss 1, Pp 1-9 (2024) |
| بيانات النشر: |
BMC, 2024. |
| سنة النشر: |
2024 |
| المجموعة: |
LCC:Diseases of the respiratory system |
| مصطلحات موضوعية: |
KL6, Interstitial lung disease, Autoimmune diseases, Computed tomography, Diseases of the respiratory system, RC705-779 |
| الوصف: |
Abstract Background Interstitial lung diseases associated with connective tissue diseases (CTD-ILD) necessitate reliable biomarkers for effective management. This study assesses the utility of serial Krebs von den Lungen-6 (KL-6) measurements in predicting disease activity and progression in CTD-ILD patients. Methods In a prospective cohort study at a tertiary care center, 50 patients with CTD at risk of or diagnosed with ILD were enrolled. KL-6 levels and pulmonary function tests (PFTs) were measured at baseline, 6, and 12 months, alongside high-resolution computed tomography (HRCT). Results Initial KL-6 levels were inversely correlated with PFTs, with mean values starting at 504.96 U/mL (SD ± 508.46), escalating to 739.42 U/mL (SD ± 612.75) at 6 months, and peaking at 1150.27 U/mL (SD ± 1106.70) by 12 months, reflecting disease progression. Higher KL-6 levels were consistently linked with declines in Forced Vital Capacity (FVC) (p = 0.019) and Diffusing Capacity for Carbon Monoxide (DLCO) (p |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1471-2466 |
| Relation: |
https://doaj.org/toc/1471-2466 |
| DOI: |
10.1186/s12890-024-03264-7 |
| URL الوصول: |
https://doaj.org/article/506565e65d0d4d27bf4fcdb4567d0bcf |
| رقم الانضمام: |
edsdoj.506565e65d0d4d27bf4fcdb4567d0bcf |
| قاعدة البيانات: |
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