التفاصيل البيبلوغرافية
| العنوان: |
Preparation and characterization of nintedanib nano-liposomes |
| المؤلفون: |
RAO Le, GUO Mengyu, XU Guogang |
| المصدر: |
陆军军医大学学报, Vol 46, Iss 14, Pp 1695-1700 (2024) |
| بيانات النشر: |
Editorial Office of Journal of Army Medical University, 2024. |
| سنة النشر: |
2024 |
| المجموعة: |
LCC:Medicine (General) |
| مصطلحات موضوعية: |
nintedanib esylate, liposome, particle sizes, ethanol injection method, Medicine (General), R5-920 |
| الوصف: |
Objective To investigate the key physical and chemical properties of nintedanib liposomes prepared by 4 different methods in order to screen out the best preparation method of nintedanib liposomes. Methods Firstly, nintedanib liposomes were prepared by thin film dispersion, reverse evaporation, ethanol injection and modified ethanol injection, respectively. The entrapment efficiency of nintedanib liposomes was then determined by dialysis and characterized for particle size, dispersibility, surface potential, and morphology. Their stability was evaluated after being placed at room temperature for 7 d. Results Circular nintedanib liposomes were respectively prepared by thin film dispersion, reverse evaporation, ethanol injection and modified ethanol injection, with a particle size of (285.1±12.3), (271.4±5.9), (226.3±14.8) and (197.2±11.2) nm, an encapsulation rate of (15.82±1.26)%, (16.71±1.35)%, (25.12±3.21)% and (32.5±3.61)%, respectively. The nintedanib liposomes prepared by modified ethanol injection had significantly smallest particle size and highest encapsulation efficiency than the liposomes by the other 3 methods (P < 0.05). In 7 d after being placed at room temperature, the particle sizes of the liposomes prepared by film dispersion and reverse evaporation were increased notably (P < 0.01), but no such change was observed in the liposomes prepared by ethanol injection and modified ethanol injection (P>0.05). Conclusion Nintedanib liposomes prepared by modified ethanol injection have excellent key physical and chemical properties, and this method is an optical one for preparing nintedanib liposomes. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
Chinese |
| تدمد: |
2097-0927 |
| Relation: |
https://aammt.tmmu.edu.cn/html/202402025.htm; https://doaj.org/toc/2097-0927 |
| DOI: |
10.16016/j.2097-0927.202402025 |
| URL الوصول: |
https://doaj.org/article/4fbbdea62a844519843a091928c909eb |
| رقم الانضمام: |
edsdoj.4fbbdea62a844519843a091928c909eb |
| قاعدة البيانات: |
Directory of Open Access Journals |