التفاصيل البيبلوغرافية
| العنوان: |
Clinical implications and molecular mechanisms of Cyclin-dependent kinases 4 for patients with hepatocellular carcinoma |
| المؤلفون: |
Zhong-liu Wei, Xin Zhou, Chen-lu Lan, Hua-sheng Huang, Xi-wen Liao, Shu-tian Mo, Yong-guang Wei, Tao Peng |
| المصدر: |
BMC Gastroenterology, Vol 22, Iss 1, Pp 1-17 (2022) |
| بيانات النشر: |
BMC, 2022. |
| سنة النشر: |
2022 |
| المجموعة: |
LCC:Diseases of the digestive system. Gastroenterology |
| مصطلحات موضوعية: |
Cyclin-dependent kinases, Hepatocellular carcinoma, Prognosis, Biomarker, Diseases of the digestive system. Gastroenterology, RC799-869 |
| الوصف: |
Abstract Background Hepatocellular carcinoma (HCC) was frequently considered as a kind of malignant tumor with a poor prognosis. Cyclin-dependent kinases (CDK) 4 was considered to be cell-cycle-related CDK gene. In this study, we explored the clinical significance of CDK4 in HCC patients. Methods Data of HCC patients were obtained from The Cancer Genome Atlas database (TCGA) and the Gene Expression Omnibus (GEO) database. Kaplan–Meier analysis and Cox regression model were performed to calculate median survival time (MST) and the hazard ration (HR), respectively. The joint-effect analysis and prognostic risk score model were constructed to demonstrate significance of prognosis-related genes. The differential expression of prognostic genes was further validated using reverse transcription-quantitative PCR (RT-qPCR) of 58 pairs of HCC samples. Results CDK1 and CDK4 were considered prognostic genes in TCGA and GSE14520 cohort. The result of joint-effect model indicated patients in CDK1 and CDK4 low expression groups had a better prognosis in TCGA (adjusted HR = 0.491; adjusted P = 0.003) and GSE14520 cohort (adjusted HR = 0.431; adjusted P = 0.002). Regarding Kaplan–Meier analysis, high expression of CDK1 and CDK4 was related to poor prognosis in both the TCGA (P |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1471-230X |
| Relation: |
https://doaj.org/toc/1471-230X |
| DOI: |
10.1186/s12876-022-02152-w |
| URL الوصول: |
https://doaj.org/article/d4f891a4ebe7490c9df1409ccc10380d |
| رقم الانضمام: |
edsdoj.4f891a4ebe7490c9df1409ccc10380d |
| قاعدة البيانات: |
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