Abnormal S100A8 expression associates with postoperative recurrence in chronic rhinosinusitis with nasal polyps

التفاصيل البيبلوغرافية
العنوان:	Abnormal S100A8 expression associates with postoperative recurrence in chronic rhinosinusitis with nasal polyps
المؤلفون:	Xiaocong Deng, Yingbin Zhao, Di Wu, Yong Qian
المصدر:	Heliyon, Vol 10, Iss 1, Pp e24295- (2024)
بيانات النشر:	Elsevier, 2024.
سنة النشر:	2024
المجموعة:	LCC:Science (General) LCC:Social sciences (General)
مصطلحات موضوعية:	Chronic rhinosinusitis with nasal polyps, S100A8, Recurrence, Biomarker, Science (General), Q1-390, Social sciences (General), H1-99
الوصف:	Objective: To investigate the role of S100A8 in chronic rhinosinusitis with nasal polyps (CRSwNP) and assess its value in predicting disease recurrence after surgery. Methods: Thirty healthy controls (HC), 30 patients with chronic rhinosinusitis without nasal polyp (CRSsNP), and 60 patients with CRSwNP were enrolled. Serum S100A8 concentration was measured by ELISA. Immunohistochemistry (IHC), western blotting (WB), and reverse transcription-polymerase chain reaction (RT-PCR)were performed to examine tissue expression levels of S100A8. The potential values of S100A8 in predicting postoperative recurrence of CRSwNP were assessed by the receiver operating characteristic (ROC)curve. Results: Serum S100A8 concentrations in the CRSwNP group were higher than the HC group and the CRSsNP group， especially in the recurrent CRSwNP group (P
نوع الوثيقة:	article
وصف الملف:	electronic resource
اللغة:	English
تدمد:	2405-8440
Relation:	http://www.sciencedirect.com/science/article/pii/S2405844024003268; https://doaj.org/toc/2405-8440
DOI:	10.1016/j.heliyon.2024.e24295
URL الوصول:	https://doaj.org/article/a4e70555fc6a4ec79825eb4a7207b1d9
رقم الانضمام:	edsdoj.4e70555fc6a4ec79825eb4a7207b1d9
قاعدة البيانات:	Directory of Open Access Journals

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الوصف
تدمد:	24058440
DOI:	10.1016/j.heliyon.2024.e24295