Academic Journal
The effects of 2,3-diphosphoglycerate, adenosine triphosphate, and glycosylated hemoglobin on the hemoglobin-oxygen affinity of diabetic patients
| العنوان: | The effects of 2,3-diphosphoglycerate, adenosine triphosphate, and glycosylated hemoglobin on the hemoglobin-oxygen affinity of diabetic patients |
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| المؤلفون: | E.M. Castilho, M.L. Glass, J.C. Manço |
| المصدر: | Brazilian Journal of Medical and Biological Research, Vol 36, Iss 6, Pp 731-737 (2003) |
| بيانات النشر: | Associação Brasileira de Divulgação Científica, 2003. |
| سنة النشر: | 2003 |
| المجموعة: | LCC:Medicine (General) LCC:Biology (General) |
| مصطلحات موضوعية: | Oxygen delivery, Diabetes mellitus, Oxygen dissociation curve, 2,3-Diphosphoglycerate, IDDM, NIDDM, Glycosylated hemoglobin, Medicine (General), R5-920, Biology (General), QH301-705.5 |
| الوصف: | The position of the oxygen dissociation curve (ODC) is modulated by 2,3-diphosphoglycerate (2,3-DPG). Decreases in 2,3-DPG concentration within the red cell shift the curve to the left, whereas increases in concentration cause a shift to the right of the ODC. Some earlier studies on diabetic patients have reported that insulin treatment may reduce the red cell concentrations of 2,3-DPG, causing a shift of the ODC to the left, but the reports are contradictory. Three groups were compared in the present study: 1) nondiabetic control individuals (N = 19); 2) insulin-dependent diabetes mellitus (IDDM) patients (on insulin treatment) (N = 19); 3) non-insulin-dependent diabetes mellitus (NIDDM) patients using oral hypoglycemic agents and no insulin treatment (N = 22). The overall position of the ODC was the same for the three groups despite an increase of the glycosylated hemoglobin fraction that was expected to shift the ODC to the left in both groups of diabetic patients (HbA1c: control, 4.6%; IDDM, 10.5%; NIDDM, 9.0%). In IDDM patients, the effect of the glycosylated hemoglobin fraction on the position of the ODC appeared to be counterbalanced by small though statistically significant increases in 2,3-DPG concentration from 2.05 (control) to 2.45 µmol/ml blood (IDDM). Though not statistically significant, an increase of 2,3-DPG also occurred in NIDDM patients, while red cell ATP levels were the same for all groups. The positions of the ODC were the same for control subjects, IDDM and NIDDM patients. Thus, the PO2 at 50% hemoglobin-oxygen saturation was 26.8, 28.2 and 28.5 mmHg for control, IDDM and NIDDM, respectively. In conclusion, our data question the idea of adverse side effects of insulin treatment on oxygen transport. In other words, the shift to the left reported by others to be caused by insulin treatment was not detected. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0100-879X 1414-431X |
| Relation: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000600008; https://doaj.org/toc/0100-879X; https://doaj.org/toc/1414-431X |
| DOI: | 10.1590/S0100-879X2003000600008 |
| URL الوصول: | https://doaj.org/article/4e1079ba795a41e3ac6b660c3d0eb277 |
| رقم الانضمام: | edsdoj.4e1079ba795a41e3ac6b660c3d0eb277 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 0100879X 1414431X |
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| DOI: | 10.1590/S0100-879X2003000600008 |