التفاصيل البيبلوغرافية
| العنوان: |
PD-1/PD-L1 governed cross-talk of exhausted CD8+ T and memory B cells in systemic lupus erythematosus |
| المؤلفون: |
Fangfang Sun, Kaiwen Wang, Shuang Ye, Jia Li, Liou Cao, Shuangjun He, Jiangfeng Zhao, Xuemei Feng, Zhangling Xu, Haiting Yang, Jiaer Ye |
| المصدر: |
RMD Open, Vol 10, Iss 1 (2024) |
| بيانات النشر: |
BMJ Publishing Group, 2024. |
| سنة النشر: |
2024 |
| المجموعة: |
LCC:Medicine |
| مصطلحات موضوعية: |
Medicine |
| الوصف: |
Background Indeterminate readout of the quantitative interferon-γ release test (QFT) for Mycobacterium tuberculosis screening is a specific laboratory finding for systemic lupus erythematosus (SLE), which may be due to T-cell exhaustion and abnormal programmed death receptor 1 (PD-1)/programmed death-ligand 1 (PD-L1) signalling.Methods We enrolled 104 patients with SLE and 225 with other rheumatic musculoskeletal diseases (RMDs) who presented to the outpatient clinic between 2020 and 2023. Twenty healthy donors served as the controls. The QFT was performed in all participants, and those with indeterminate results were compared among the groups. Immunophenotyping and functional assays were performed using blood mononuclear cells. Interferon (IFN)-γ was detected in vitro and ex vivo in patients with SLE with indeterminate or negative QFT results, before or after rituximab therapy.Results 104 patients with SLE had a significantly higher rate of indeterminate QFT results was significantly higher (17.31%) than that of 225 patients with RMD (3.56%). Patients with SLE with indeterminate QFT had more active disease (SLEDAI-2K, mean 10.94 vs 4.02, p |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2056-5933 |
| Relation: |
https://rmdopen.bmj.com/content/10/1/e003503.full; https://doaj.org/toc/2056-5933 |
| DOI: |
10.1136/rmdopen-2023-003503 |
| URL الوصول: |
https://doaj.org/article/e4dc5475ecde49eba69e06b996269d29 |
| رقم الانضمام: |
edsdoj.4dc5475ecde49eba69e06b996269d29 |
| قاعدة البيانات: |
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