التفاصيل البيبلوغرافية
| العنوان: |
American ginseng significantly reduced the progression of high-fat-diet-enhanced colon carcinogenesis in ApcMin/+mice |
| المؤلفون: |
Chunhao Yu, Xiao-Dong Wen, Zhiyu Zhang, Chun-Feng Zhang, Xiaohui Wu, Xin He, Yang Liao, Ningning Wu, Chong-Zhi Wang, Wei Du, Tong-Chuan He, Chun-Su Yuan |
| المصدر: |
Journal of Ginseng Research, Vol 39, Iss 3, Pp 230-237 (2015) |
| بيانات النشر: |
Elsevier, 2015. |
| سنة النشر: |
2015 |
| المجموعة: |
LCC:Botany |
| مصطلحات موضوعية: |
ApcMin/+mice, colorectal cancer, ginsenoside metabolites, inflammatory cytokines, Panax quinquefolius L., Botany, QK1-989 |
| الوصف: |
Background: Colorectal cancer (CRC) is a leading cause of death worldwide. Chronic gut inflammation is recognized as a risk factor for tumor development, including CRC. American ginseng is a very commonly used ginseng species in the West. Methods: A genetically engineered ApcMin/+ mouse model was used in this study. We analyzed the saponin composition of American ginseng used in this project, and evaluated its effects on the progression of high-fat-diet-enhanced CRC carcinogenesis. Results: After oral ginseng administration (10–20 mg/kg/d for up to 32 wk), experimental data showed that, compared with the untreated mice, ginseng very significantly reduced tumor initiation and progression in both the small intestine (including the proximal end, middle end, and distal end) and the colon (all p |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1226-8453 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S1226845315000020; https://doaj.org/toc/1226-8453 |
| DOI: |
10.1016/j.jgr.2014.12.004 |
| URL الوصول: |
https://doaj.org/article/4dac43db20194b6f86923ee9c6d57cc8 |
| رقم الانضمام: |
edsdoj.4dac43db20194b6f86923ee9c6d57cc8 |
| قاعدة البيانات: |
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