التفاصيل البيبلوغرافية
| العنوان: |
α-Amylase and α-glucosidase inhibitory activities of the extracts and constituents of Ferulago blancheana, F. pachyloba and F. trachycarpa roots |
| المؤلفون: |
Songül Karakaya, Hilal Özbek, Sefa Gözcü, Zühal Güvenalp, Hafize Yuca, Hayri Duman, Cavit Kazaz, Ceyda Sibel Kiliç |
| المصدر: |
Bangladesh Journal of Pharmacology, Vol 13, Iss 1 (2018) |
| بيانات النشر: |
Bangladesh Pharmacological Society, 2018. |
| سنة النشر: |
2018 |
| المجموعة: |
LCC:Therapeutics. Pharmacology |
| مصطلحات موضوعية: |
Apiaceae, α-Amylase, α-Glucosidase, Coumarin, Ferulago blancheana, F. pachyloba, Therapeutics. Pharmacology, RM1-950 |
| الوصف: |
Eleven coumarins named osthole (1), imperatorin (2), bergapten (3), prantschimgin (4), grandivitinol (5), suberosin (6), xanthotoxin (7), felamidin (8), marmesin (9), umbelliferone (10), ulopterol (11), and a sterol mixture consisted of stigmasterol (12), β-sitosterol (13) were isolated from the roots of Ferulago blancheana, F. pachyloba and F. trachycarpa through in vitro bioassay-guided fractionation processes. The extracts and bioactive compounds were evaluated for their α-amylase and α-glucosidase activities. Among the tested compounds, felamidin and suberosin showed significant α-glucosidase inhibitory activity with IC50 values of 0.4 and 0.9 mg/mL, respectively, when compared to the reference standard acarbose (IC50 = 4.9 mg/mL). Grandivitinol (IC50 = 20.0 mg/mL) had the lowest inhibitory effect. On the other hand, none of the tested extracts were found to be active on α-amylase inhibition. This is the first report on isolation, characterization of the bioactive compounds and evaluation the α-amylase and α-glucosidase inhibitory activities of these species. Video Clip of Methodology: 8 min 26 sec: Full Screen Alternate |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1991-0088 |
| Relation: |
https://www.banglajol.info/index.php/BJP/article/view/33668; https://doaj.org/toc/1991-0088 |
| DOI: |
10.3329/bjp.v13i1.33668 |
| URL الوصول: |
https://doaj.org/article/4d395db697894e7380557032fe53f529 |
| رقم الانضمام: |
edsdoj.4d395db697894e7380557032fe53f529 |
| قاعدة البيانات: |
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