Academic Journal
Systematic review of pharmacoeconomic models for schizophrenia
| العنوان: | Systematic review of pharmacoeconomic models for schizophrenia |
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| المؤلفون: | Junwen Zhou, Aurélie Millier, Mondher Toumi |
| المصدر: | Journal of Market Access & Health Policy, Vol 6, Iss 1 (2018) |
| بيانات النشر: | Taylor & Francis Group, 2018. |
| سنة النشر: | 2018 |
| المجموعة: | LCC:Public aspects of medicine LCC:Business |
| مصطلحات موضوعية: | Schizophrenia, pharmacotherapy, antipsychotics, pharmacoeconomics, economic model, model structure, Public aspects of medicine, RA1-1270, Business, HF5001-6182 |
| الوصف: | Background: Economic models are broadly used in the economic evaluation of antipsychotics in schizophrenia. Our objective was to summarize the structure of these models. Methods: Model-based economic evaluations of antipsychotics in schizophrenia were identified through Medline and Embase. General information was extracted including analysis type, model type, perspective, population, comparator, outcome, and timeframe. Model-specific structures for decision tree (DT), cohort- and patient-level Markov model (CLMM, PLMM), and discrete-event simulation (DES) models were extracted. Results: A screen of 1870 records identified 79 studies. These were mostly cost-utility analyses (n = 48) with CLMM (n = 32) or DT models (n = 29). They mostly applied payer perspective (n = 68), focused on general schizophrenia for relapse prevention (n = 73), compared pharmacotherapies as first-line (n = 71), and evaluated incremental cost per quality-adjusted life year (QALY) gained (n = 40) with a 1-year (n = 32) or 5-year (n = 26) projection. DT models progressed with the branching points of response, relapse, discontinuation, and adherence. CLMM models transitioned between disease states, whereas PLMM models transitioned between adverse event states with/without disease state. DES models moved forward with times to remission, relapse, psychiatrist visit, and death. Conclusions: A pattern of pharmacoeconomic models for schizophrenia was identified. More subtle structures and patient-level models are suggested for a future modelling exercise. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2001-6689 20016689 |
| Relation: | https://doaj.org/toc/2001-6689 |
| DOI: | 10.1080/20016689.2018.1508272 |
| URL الوصول: | https://doaj.org/article/4c663068323b4819889ec3e785a999ca |
| رقم الانضمام: | edsdoj.4c663068323b4819889ec3e785a999ca |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20016689 |
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| DOI: | 10.1080/20016689.2018.1508272 |