Academic Journal
Recent Advances in Simulation Studies on the Protein Corona
| العنوان: | Recent Advances in Simulation Studies on the Protein Corona |
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| المؤلفون: | Hwankyu Lee |
| المصدر: | Pharmaceutics, Vol 16, Iss 11, p 1419 (2024) |
| بيانات النشر: | MDPI AG, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Pharmacy and materia medica |
| مصطلحات موضوعية: | protein corona, molecular dynamics simulation, protein–nanoparticle interaction, protein–protein interaction, drug delivery, Pharmacy and materia medica, RS1-441 |
| الوصف: | When flowing through the blood stream, drug carriers such as nanoparticles encounter hundreds of plasma proteins, forming a protein layer on the nanoparticle surface, known as the “protein corona”. Since the protein corona influences the size, shape, and surface properties of nanoparticles, it can modulate their circulating lifetime, cytotoxicity, and targeting efficiency. Therefore, understanding the mechanism of protein corona formation at the atomic scale is crucial, which has become possible due to advances in computer power and simulation methodologies. This review covers the following topics: (1) the structure, dynamics, and composition of protein corona on nanoparticles; (2) the effects of protein concentration and ionic strength on protein corona formation; (3) the effects of particle size, morphology, and surface properties on corona formation; (4) the interactions among lipids, membranes, and nanoparticles with the protein corona. For each topic, mesoscale, coarse-grained, and all-atom molecular dynamics simulations since 2020 are discussed. These simulations not only successfully reproduce experimental observations but also provide physical insights into the protein corona formation. In particular, these simulation findings can be applied to manipulate the formation of a protein corona that can target specific cells, aiding in the rational design of nanomedicines for drug delivery applications. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 16111419 1999-4923 |
| Relation: | https://www.mdpi.com/1999-4923/16/11/1419; https://doaj.org/toc/1999-4923 |
| DOI: | 10.3390/pharmaceutics16111419 |
| URL الوصول: | https://doaj.org/article/4c661304b3234b78977aa975030a9e27 |
| رقم الانضمام: | edsdoj.4c661304b3234b78977aa975030a9e27 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 16111419 19994923 |
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| DOI: | 10.3390/pharmaceutics16111419 |