التفاصيل البيبلوغرافية
| العنوان: |
Relationship between early proteinuria and long term outcome of kidney transplanted patients from different decades of donor age |
| المؤلفون: |
Davide Diena, Maria Messina, Consuelo De Biase, Fabrizio Fop, Edoardo Scardino, Maura M. Rossetti, Antonella Barreca, Aldo Verri, Luigi Biancone |
| المصدر: |
BMC Nephrology, Vol 20, Iss 1, Pp 1-15 (2019) |
| بيانات النشر: |
BMC, 2019. |
| سنة النشر: |
2019 |
| المجموعة: |
LCC:Diseases of the genitourinary system. Urology |
| مصطلحات موضوعية: |
Kidney transplantation, Elderly donors, Proteinuria, Long-term outcome, Estimated glomerular filtration rate, Diseases of the genitourinary system. Urology, RC870-923 |
| الوصف: |
Abstract Background Proteinuria after kidney transplantation portends a worse graft survival. However the magnitude of proteinuria related to patient and graft survival and its correlation with donor and recipient characteristics are poorly explored. Methods This study investigated the impact of post transplant proteinuria in the first year in 1127 kidney transplants analyzing the impact of different donor ages. Proteinuria cut off was set at 0.5 g/day. Results Transplants with proteinuria > 0.5 g/day correlated with poor graft and patient outcome in all donor age groups. In addition, 6-month-1-year proteinuria increase was significantly associated with graft outcome, especially with donors > 60 years old (p 50 years old (Odd Ratio 2.3). Conclusions Post-transplant proteinuria was increasingly harmful with older donor age. Proteinuria ≥0.5 g/day correlates with worse outcomes in all transplanted patients. Prognostic value of proteinuria and eGFR for graft and patient survival was comparable and these two variables remain significant risk factors even in a multivariate model that take into consideration the most important clinical variables (donor age, rejection, delayed graft function and cytomegalovirus viremia among others). |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1471-2369 |
| Relation: |
https://doaj.org/toc/1471-2369 |
| DOI: |
10.1186/s12882-019-1635-0 |
| URL الوصول: |
https://doaj.org/article/4c3bdd7eee6840f095f911b4a6bc6eff |
| رقم الانضمام: |
edsdoj.4c3bdd7eee6840f095f911b4a6bc6eff |
| قاعدة البيانات: |
Directory of Open Access Journals |
Full Text Finder