التفاصيل البيبلوغرافية
| العنوان: |
Get real: Orbitofrontal cortex mediates the ability to sense reality in early adolescents |
| المؤلفون: |
Maria Chiara Liverani, Lorena G. A. Freitas, Vanessa Siffredi, Greta Mikneviciute, Roberto Martuzzi, Djalel‐Eddine Meskaldij, Cristina Borradori Tolsa, Russia Ha‐Vinh Leuchter, Armin Schnider, Dimitri Van De Ville, Petra Susan Hüppi |
| المصدر: |
Brain and Behavior, Vol 10, Iss 4, Pp n/a-n/a (2020) |
| بيانات النشر: |
Wiley, 2020. |
| سنة النشر: |
2020 |
| المجموعة: |
LCC:Neurosciences. Biological psychiatry. Neuropsychiatry |
| مصطلحات موضوعية: |
early adolescents, fMRI, memory, orbitofrontal cortex, orbitofrontal reality filtering, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571 |
| الوصف: |
Abstract Introduction Orbitofrontal reality filtering (ORFi) is a memory mechanism that distinguishes whether a thought is relevant to present reality or not. In adults, it is mediated by the orbitofrontal cortex (OFC). This region is still not fully developed in preteenagers, but ORFi is already active from age 7. Here, we probe the neural correlates of ORFi in early adolescents, hypothesizing that OFC mediates the sense of reality in this population. Methods Functional magnetic resonance images (fMRI) were acquired in 22 early adolescents during a task composed of two runs: run 1 measuring recognition capacity; run 2 measuring ORFi; each containing two types of images (conditions): distractors (D: images seen for the first time in the current run) and targets (T: images seen for the second time in the current run). Group region of interest (ROI) analysis was performed in a flexible factorial design with two factors (run and condition) using SPM12. Results We found significant main effects for the experimental run and condition. The bilateral OFC activation was higher during ORFi than during the first run. Additionally, the OFC was more active while processing distractors than targets. Conclusion These results confirm, for the first time, the role of OFC in reality filtering in early adolescents. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2162-3279 |
| Relation: |
https://doaj.org/toc/2162-3279 |
| DOI: |
10.1002/brb3.1552 |
| URL الوصول: |
https://doaj.org/article/4b829118ad7e4edc90943c0b80ae64d5 |
| رقم الانضمام: |
edsdoj.4b829118ad7e4edc90943c0b80ae64d5 |
| قاعدة البيانات: |
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