Academic Journal
Atypical BCR-ABL mRNA transcripts in adult Acute lymphoblastic leukemia
| العنوان: | Atypical BCR-ABL mRNA transcripts in adult Acute lymphoblastic leukemia |
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| المؤلفون: | Thomas Burmeister, Stefan Schwartz, Almut Taubald, Edgar Jost, Thomas Lipp, Folker Schneller, Helmut Diedrich, Henrike Thomssen, Ulrich J.M. Mey, Jan Eucker, Harald Rieder, Nicola Gökbuget, Dieter Hoelzer, Eckhard Thiel |
| المصدر: | Haematologica, Vol 92, Iss 12 (2007) |
| بيانات النشر: | Ferrata Storti Foundation, 2007. |
| سنة النشر: | 2007 |
| المجموعة: | LCC:Diseases of the blood and blood-forming organs |
| مصطلحات موضوعية: | Diseases of the blood and blood-forming organs, RC633-647.5 |
| الوصف: | RT-PCR detects chimeric BCR-ABL mRNA in approximately 25% of adult acute lymphoblastic leukemia (ALL) cases. Minor breakpoint transcripts (e1a2) are found in about 70% of positive cases and major breakpoint transcripts (e13a2, e14a2) in about 30% of cases. However, other atypical transcripts are sometimes observed. We report experience gained in the GMALL Study Group and identified 8 BCR-ABL-positive adult ALL cases with such atypical transcripts: 5 with e1a3, 2 with e13a3 (b2a3), and 1 with e6a2. This corresponds to a prevalence of 1–2% of all BCR-ABL-positive cases. The clinical courses are reported and diagnostic proposals are made. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0390-6078 1592-8721 |
| Relation: | https://haematologica.org/article/view/4673; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721 |
| DOI: | 10.3324/haematol.11737 |
| URL الوصول: | https://doaj.org/article/4b81c2dedc4f4bfd9a07148b9e5bfeef |
| رقم الانضمام: | edsdoj.4b81c2dedc4f4bfd9a07148b9e5bfeef |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 03906078 15928721 |
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| DOI: | 10.3324/haematol.11737 |