Academic Journal
Antibacterial microneedle patch releases oxygen to enhance diabetic wound healing
| العنوان: | Antibacterial microneedle patch releases oxygen to enhance diabetic wound healing |
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| المؤلفون: | Mengli Sun, Xiqiang Zhong, Minghai Dai, Xujun Feng, Chengxuan Tang, Lingling Cao, Liangle Liu |
| المصدر: | Materials Today Bio, Vol 24, Iss , Pp 100945- (2024) |
| بيانات النشر: | Elsevier, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Medicine (General) LCC:Biology (General) |
| مصطلحات موضوعية: | Silk fibroin methacryloyl, Microneedle, Diabetic wound healing, Calcium peroxide, Oxygen generation, Medicine (General), R5-920, Biology (General), QH301-705.5 |
| الوصف: | Cell growth and metabolism require an adequate supply of oxygen. However, obtaining sufficient oxygen from the blood circulating around diabetic wounds is challenging. Nevertheless, achieving a continuous and stable oxygen supply is required for these wounds to heal. Hence, in this study, we report a novel antibacterial oxygen-producing silk fibroin methacryloyl hydrogel microneedle (MN) patch comprising tips encapsulated with calcium peroxide and catalase and a base coated with antibacterial Ag nanoparticles (AgNPs). The tip of the MN patch continuously releases oxygen and inhibits the production of reactive oxygen species. This accelerates diabetic wound healing by promoting cellular accretion and migration, macrophage M2 polarization, and angiogenesis. The AgNPs at the base of the MN patch effectively combat microbial infection, further facilitating wound repair. These findings suggest that using this multifunctional oxygen-producing MN patch may be a promising strategy for diabetic wound healing in clinical settings. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2590-0064 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2590006424000048; https://doaj.org/toc/2590-0064 |
| DOI: | 10.1016/j.mtbio.2024.100945 |
| URL الوصول: | https://doaj.org/article/aec4b6ad2d6e4498880b3260a88a887e |
| رقم الانضمام: | edsdoj.4b6ad2d6e4498880b3260a88a887e |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 25900064 |
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| DOI: | 10.1016/j.mtbio.2024.100945 |